Serum calprotectin levels in dogs with diarrhea

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dc.authorid0000-0002-2006-6344en_US
dc.authorid0000-0003-0199-453Xen_US
dc.authorid0000-0002-2952-5180en_US
dc.authorid0000-0002-7486-232Xen_US
dc.authorid0000-0002-6034-3203en_US
dc.contributor.authorŞimşek, Aynur
dc.contributor.authorKoçhan, Akın
dc.contributor.authorAlp, Simten Yeşilmen
dc.contributor.authorİpek, Duygu Neval Sayın
dc.contributor.authorİçen, Hasan
dc.date.accessioned2023-04-26T07:33:40Z
dc.date.available2023-04-26T07:33:40Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Diarrhea induced by infectious factors may lead to significant health problems in dogs. Canine parvovirus (CPV), canine coronavirus (CCV), canine distemper virus (CDV), Giardia spp., Escherichia coli (E. coli), and Salmonella spp. are the important infectious agents that may induce diarrhea in dogs. The present study aimed to investigate the effect of CPV, CCV, CDV, Giardia spp., E. coli, and Salmonella spp. infections on the change in serum calprotectin (Calp) concentration. Materials, Methods & Results: A total of 30 dogs were enrolled in the study. The study dogs were divided into 3 groups. Healthy animals as confirmed by clinical examination and animals negative for the specified pathogens were placed in Group 1. Animals infected by one or more agents, including CPV, CCV, CDV, and Giardia spp., but negative for E. coli or Salmonella spp. were placed in Group 2. Finally, animals positive for E. coli or Salmonella spp. and infected or not infected by one or more agents, including CPV, CCV, CDV, and Giardia spp., were placed in Group 3. Stool samples and rectal and conjunctival swab samples were collected to investigate the etiologic agents that induced diarrhea. Blood samples were collected through vena cephalica antebrachii for hematological and biochemical examinations. The samples were obtained via routine clinical examinations at the Prof. Dr. Servet Sekin outpatient clinic at Dicle University Veterinary Faculty. CPV, CCV, CDV, and Giardia spp. diagnoses were made based on immunochromatographic test kits. The bacteriological analysis of stool samples was used to diagnose E. coli and Salmonella spp. infection. Serum Calp concentrations were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The analysis of swab and stool samples by immunochromatographic rapid diagnosis kits and microbiological methods showed that 5 animals were infected with CPV, 10 with CCV, 6 with CDV, 3 with Giardia spp., 12 with E. coli, and 2 with none of the specified agents. Total leukocyte count (WBC), lymphocyte (Lym - %), and granulocyte (Gra - %) values were higher in the diarrheal dogs when compared with the control group. In the biochemical examination of serum samples, total bilirubin (TBIL) and phosphorus (P) levels were higher and sodium (Na) levels were lower in Group 3 when compared to the control group (P = 0.025, 0.024, and 0.018, respectively). Total protein (TP) and albumin (Alb) values were lower in Group 2 compared to Groups 1 and 3 [P = 0.001 and 0.019 for TP, P = 0.000 and 0.01 for Alb, respectively]. There was a statistically significant difference in creatine kinase (CK) levels between Group 1 and Group 2 (P = 0.013). Serum Calp level was higher in the E. coli infected group (Group 3) compared to the other groups, no significant differences were noted between the groups (P > 0.05). Discussion: In conclusion, to the best of authors knowledge, this study is the first to evaluate serum Calp levels in dogs with diarrhea induced by viral, bacterial, and protozoan infections. The Calp level was higher in the sick dogs that were infected by at least one agent, including CPV, CCV, CDV, and Giardia spp., and were at the same time E. coli positive when compared with the control group and the group without E. coli infections. It was concluded that new studies could be useful to reveal the diagnostic importance of serum Calp concentration in dogs with diarrhea and that these results may contribute to future studies in this area.en_US
dc.description.sponsorshipDicle University-Veterinary.17.018en_US
dc.identifier.citationŞimşek, A., Koçhan, A., Alp, S.Y., İpek, D.N.S. ve İçen, H. (2022). Serum calprotectin levels in dogs with diarrhea. Acta Scientiae Veterinariae, 50, 1850en_US
dc.identifier.doi10.22456/1679-9216.119992
dc.identifier.endpage8en_US
dc.identifier.issn1678-0345
dc.identifier.issn1679-9216
dc.identifier.scopus2-s2.0-85128777568
dc.identifier.scopusqualityQ4
dc.identifier.startpage1en_US
dc.identifier.urihttps://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/119992
dc.identifier.urihttps://hdl.handle.net/11468/11747
dc.identifier.volume50en_US
dc.identifier.wosWOS:000796716000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞimşek, Aynur
dc.institutionauthorKoçhan, Akın
dc.institutionauthorAlp, Simten Yeşilmen
dc.institutionauthorİpek, Duygu Neval Sayın
dc.institutionauthorİçen, Hasan
dc.language.isoenen_US
dc.publisherUniv Fed Rio Grande Do Sulen_US
dc.relation.ispartofActa Scientiae Veterinariae
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalprotectinen_US
dc.subjectDiarrheaen_US
dc.subjectDogen_US
dc.subjectGastroenteritisen_US
dc.subjectEnteropathogensen_US
dc.subjectEnterotoxinsen_US
dc.subjectIntestinal diseasesen_US
dc.titleSerum calprotectin levels in dogs with diarrheaen_US
dc.titleSerum calprotectin levels in dogs with diarrhea
dc.typeArticleen_US

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