Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension

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dc.contributor.authorAybak, M
dc.contributor.authorSermet, A
dc.contributor.authorAyyildiz, MO
dc.contributor.authorKarakilcik, AZ
dc.date.accessioned2024-04-24T17:33:35Z
dc.date.available2024-04-24T17:33:35Z
dc.date.issued1995
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to test the effect of vitamin B-6 (pyridoxine-HCl, CAS 58-56-0) supplementation on arterial blood pressure in essential hypertension. The trial comprised 9 normotensive subjects (7 men and 2 women, aged between 32-58 years, mean +/- SD, 48 +/- 11) and 20 patients with essential hypertension (16 men and 4 women, aged between 32-69 years, mean +/- SD, 56 +/- 12). The patients were treated during 4 weeks with a single oral dose of pyridoxine (5 mg/kg body weight/day). After a 5-min rest, measurements were made in the supine position. When compared with the normotensive subjects, the hypertensive subject group had a significantly higher systolic and diastolic blood pressure (p < 0.001) and higher level of plasma norepinephrine (E) (p < 0.01) before pyridoxine treatment. On the other hand there, were no significant differences in plasma epinephrine (E) and heart rates. Treatment of hypertensive patients with pyridoxine significantly reduced systolic (p < 0.01) and diastolic blood pressure (p < 0.005), plasma NE (p < 0.005) and E (p < 0.05) within 4 weeks. However, there was no significant difference in heart rate at the end of pyridoxine treatment. These results indicate a relationship between pyridoxine status and arterial blood pressure in the essential hypertensive patients.en_US
dc.identifier.endpage1273en_US
dc.identifier.issn0004-4172
dc.identifier.issue12en_US
dc.identifier.pmid8595083
dc.identifier.scopus2-s2.0-0029569067
dc.identifier.scopusqualityN/A
dc.identifier.startpage1271en_US
dc.identifier.urihttps://hdl.handle.net/11468/20762
dc.identifier.volume45-2en_US
dc.identifier.wosWOS:A1995TN02000006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCas 58-56-0en_US
dc.subjectHypertension, Essentialen_US
dc.subjectPyridoxine, Clinical Studies, Effects On Blood Pressureen_US
dc.subjectVitamin B-6en_US
dc.titleEffect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertensionen_US
dc.titleEffect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension
dc.typeArticleen_US

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