Effect of androgen replacement therapy on atherosclerotic risk markers in young-to-middle-aged men with idiopathic hypogonadotropic hypogonadism

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dc.contributor.authorDogan, Bercem Aycicek
dc.contributor.authorKarakilic, Ersen
dc.contributor.authorTuna, Mazhar Muslum
dc.contributor.authorArduc, Ayse
dc.contributor.authorBerker, Dilek
dc.contributor.authorGueler, Serdar
dc.date.accessioned2024-04-24T17:11:26Z
dc.date.available2024-04-24T17:11:26Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectiveIdiopathic hypogonadotropic hypogonadism is a rare disorder. This study evaluated the effect of androgen replacement therapy on atherosclerotic risk markers in young-to-middle-aged men with this disorder. Design and methodsForty-three male patients aged 30 (range: 24-39years) who were newly diagnosed with idiopathic hypogonadotropic hypogonadism and 20 age-, sex- and weight-matched controls (range: 26-39years) were included in the study. Androgen replacement therapy was given according to the Algorithm of Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes (2010; Journal of Clinical Endocrinology and Metabolism, 95, 2536). The patients were assessed at a pretreatment visit and 3 and 6months after the treatment. Inflammatory markers and lipid parameters were evaluated. Endothelial function was assessed with brachial flow-mediated dilation of a brachial artery and high-resolution ultrasonography of the carotid intima-media thickness. ResultsThe carotid intima-media thickness (P<0001) was higher and the brachial flow-mediated diameter (P=0002) was lower in patients with idiopathic hypogonadotropic hypogonadism compared to the control subjects at the pretreatment visit. There was a negative correlation between the total testosterone level and carotid intima-media thickness (r=-0556, P=<0001). The carotid intima-media thickness and per cent flow-mediated diameter were significantly improved in the patient group 6months after the androgen replacement therapy (P=0002 and 0026, respectively). ConclusionsThis study indicated that low total testosterone levels can be considered a significant marker of atherosclerosis in patients with idiopathic hypogonadotropic hypogonadism and that androgen replacement therapy significantly reduces atherosclerotic risk markers in these patients after 6months.en_US
dc.identifier.doi10.1111/cen.12617
dc.identifier.endpage428en_US
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue3en_US
dc.identifier.pmid25280063
dc.identifier.scopus2-s2.0-84923039350
dc.identifier.scopusqualityQ2
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.1111/cen.12617
dc.identifier.urihttps://hdl.handle.net/11468/17509
dc.identifier.volume82en_US
dc.identifier.wosWOS:000350115600014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffect of androgen replacement therapy on atherosclerotic risk markers in young-to-middle-aged men with idiopathic hypogonadotropic hypogonadismen_US
dc.titleEffect of androgen replacement therapy on atherosclerotic risk markers in young-to-middle-aged men with idiopathic hypogonadotropic hypogonadism
dc.typeArticleen_US

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