Histopathologic results of long-term sildenafil administration on rat inner ear

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dc.contributor.authorBakir, Salih
dc.contributor.authorFirat, Ugur
dc.contributor.authorGun, Ramazan
dc.contributor.authorBozkurt, Yasar
dc.contributor.authorYorgancilar, Ediz
dc.contributor.authorKinis, Vefa
dc.contributor.authorPenbegül, Necmettin
dc.date.accessioned2024-04-24T16:10:47Z
dc.date.available2024-04-24T16:10:47Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Sildenafil, a selective inhibitor of phosphodiesterase type 5, is widely used for the treatment of erectile dysfunction. Although cochlear effects of phosphodiesterase type 5 inhibitors remain still unclear because of inadequate data, some evidence that recently emerged indicates that these medications may be responsible for hearing impairment. In the present study, we aimed to examine the histopathologic effects of long-term sildenafil use on the cochlea in a rat model. Methods: The study was performed with adult male Wistar albino rats. The control group was fed on standard laboratory diet. The study group was applied orally with sildenafil therapy, 1.5 mg/kg once a day for 45 days. Rats were anesthetized and decapitated. Each temporal bone was dissected, and the cochleas were removed en bloc. The inner-ear biopsy specimens were examined histologically with hematoxylin and eosin and caspase 3 immunoreaction under light microscopy. Results: Hematoxylin and eosin staining showed no distinctive difference between the control group and the sildenafil group. With immunohistochemical examination, caspase 3 immunoreactivity was observed in the sildenafil group. In the control group, caspase 3 immunoreactivity was not observed. Conclusions: The caspase 3 immunoreactivity in the sildenafil group was strongly associated with an increase in apoptotic events in the cochlea. Long-term use of sildenafil can cause hearing impairment through increased apoptosis. (c) 2012 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjoto.2012.04.005
dc.identifier.endpage672en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue6en_US
dc.identifier.pmid22683010
dc.identifier.scopus2-s2.0-84868340688
dc.identifier.scopusqualityQ1
dc.identifier.startpage667en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2012.04.005
dc.identifier.urihttps://hdl.handle.net/11468/15103
dc.identifier.volume33en_US
dc.identifier.wosWOS:000311128200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleHistopathologic results of long-term sildenafil administration on rat inner earen_US
dc.titleHistopathologic results of long-term sildenafil administration on rat inner ear
dc.typeArticleen_US

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