Prognostic significance of the chemerin level in coronavirus disease 2019 patients

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dc.contributor.authorGökdemir, Gül Şahika
dc.contributor.authorGökdemir, Mehmet Tahir
dc.contributor.authorAraç, Songül
dc.contributor.authorYokuş, Beran
dc.date.accessioned2024-04-24T17:56:23Z
dc.date.available2024-04-24T17:56:23Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractIncreased serum chemerin levels have been reported in several inflammatory diseases. Few studies have investigated the relationship between chemerin and clinical features of COVID-19. Thus, chemerin may modulate the development and progression of COVID-19. We compared the serum chemerin concentration between patients with and without SARS-CoV-2 infection and its association with the severity and prognosis of COVID-19 pneumonia. This is a prospective, single-center, cross-sectional study. We enrolled COVID-19 patients who presented to our tertiary hospital and healthy controls. The COVID-19 patients were conducted and the dates of symptom onset were recorded. After admission to the hospital and stabilization, blood samples were obtained for routine hemogram, biochemistry, and chemerin. The chemerin level was 37.93?±?17.3 ng/mL in patients followed in the ICU, 29.41?±?12.79 ng/mL in inpatients, 30.48?±?10.86 ng/mL in outpatients, and 25.12?±?9.82 ng/mL in healthy controls. The difference between patients treated in the ICU and healthy controls was significant (P?<?.001). The high-sensitivity C-reactive protein (hs-CRP), ferritin, procalcitonin (PCT), and D-dimer levels were significantly higher in the intensive care unit (ICU) group (P?<?.001). Moreover, the chemerin level of patients who died was significantly higher than that of those who survived (P?<?.001). The chemerin level was increased in COVID-19 patients and also increased with increasing disease severity. The chemerin level was higher in the COVID-19 patients than healthy controls and was significantly higher in patients who died compared to those who did not. © 2024 Lippincott Williams and Wilkins. All rights reserved.en_US
dc.identifier.citationGökdemir, G. Ş., Gökdemir, M. T., Araç, S. ve Yokuş, B. (2024). Prognostic significance of the chemerin level in coronavirus disease 2019 patients. Medicine (United States), 103(14), 1-6.
dc.identifier.doi10.1097/MD.0000000000037743
dc.identifier.issn0025-7974
dc.identifier.issue14en_US
dc.identifier.pmid38579052
dc.identifier.scopus2-s2.0-85190080849
dc.identifier.scopusqualityQ2
dc.identifier.startpageE37743en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000037743
dc.identifier.urihttps://hdl.handle.net/11468/23488
dc.identifier.volume103en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYokuş, Beran
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofMedicine (United States)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemerinen_US
dc.subjectCoronavirus disease 2019en_US
dc.subjectİntensive care uniten_US
dc.subjectOutpatienten_US
dc.titlePrognostic significance of the chemerin level in coronavirus disease 2019 patientsen_US
dc.titlePrognostic significance of the chemerin level in coronavirus disease 2019 patients
dc.typeArticleen_US

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