Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization

Basit Öğe Kaydı
dc.authorid0000-0003-0675-5204en_US
dc.contributor.authorChang, Hsin-Wen
dc.contributor.authorYan, Di
dc.contributor.authorSingh, Rasnik
dc.contributor.authorLiu, Jared
dc.contributor.authorLu, Xueyan
dc.contributor.authorUçmak, Derya
dc.contributor.authorLee, Kristina
dc.contributor.authorAfifi, Ladan
dc.contributor.authorFadrosh, Douglas
dc.contributor.authorLeech, John
dc.contributor.authorVasquez, Kimberly S.
dc.contributor.authorLowe, Margaret M.
dc.contributor.authorRosenblum, Michael D.
dc.contributor.authorScharschmidt, Tiffany C.
dc.contributor.authorLynch, Susan V.
dc.date.accessioned2022-12-07T13:17:57Z
dc.date.available2022-12-07T13:17:57Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalıen_US
dc.descriptionPMID: 30185226
dc.description.abstractBackground: Psoriasis impacts 1-3% of the world's population and is characterized by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level, psoriasis is commonly driven by a Th17 response, which serves as a major therapeutic target. Microbiome perturbations have been associated with several immune-mediated diseases such as atopic dermatitis, asthma, and multiple sclerosis. Although a few studies have investigated the association between the skin microbiome and psoriasis, conflicting results have been reported plausibly due to the lack of standardized sampling and profiling protocols, or to inherent microbial variability across human subjects and underpowered studies. To better understand the link between the cutaneous microbiota and psoriasis, we conducted an analysis of skin bacterial communities of 28 psoriasis patients and 26 healthy subjects, sampled at six body sites using a standardized protocol and higher sequencing depth compared to previous studies. Mouse studies were employed to examine dermal microbial-immune interactions of bacterial species identified from our study. Results: Skin microbiome profiling based on sequencing the 16S rRNA V1-V3 variable region revealed significant differences between the psoriasis-associated and healthy skin microbiota. Comparing the overall community structures, psoriasis-associated microbiota displayed higher diversity and more heterogeneity compared to healthy skin bacterial communities. Specific microbial signatures were associated with psoriatic lesional, psoriatic non-lesional, and healthy skin. Specifically, relative enrichment of Staphylococcus aureus was strongly associated with both lesional and non-lesional psoriatic skin. In contrast, Staphylococcus epidermidis and Propionibacterium acnes were underrepresented in psoriatic lesions compared to healthy skin, especially on the arm, gluteal fold, and trunk. Employing a mouse model to further study the impact of cutaneous Staphylcoccus species on the skin T cell differentiation, we found that newborn mice colonized with Staphylococcus aureus demonstrated strong Th17 polarization, whereas mice colonized with Staphylococcus epidermidis or un-colonized controls showed no such response. Conclusion: Our results suggest that microbial communities on psoriatic skin is substantially different from those on healthy skin. The psoriatic skin microbiome has increased diversity and reduced stability compared to the healthy skin microbiome. The loss of community stability and decrease in immunoregulatory bacteria such as Staphylococcus epidermidis and Propionibacterium acnes may lead to higher colonization with pathogens such as Staphylococcus aureus, which could exacerbate cutaneous inflammation along the Th17 axis.en_US
dc.identifier.citationChang, H. W., Yan, D., Singh, R., Liu, J., Lu, X. ve Uçmak, D. (2018). Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome, 6(1).en_US
dc.identifier.doi10.1186/s40168-018-0533-1
dc.identifier.issn2049-2618
dc.identifier.issue1en_US
dc.identifier.pmid30185226
dc.identifier.scopus2-s2.0-85052966412
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0533-1
dc.identifier.urihttps://hdl.handle.net/11468/10979
dc.identifier.volume6en_US
dc.identifier.wosWOS:000444353600002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Derya
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofMicrobiome
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdulten_US
dc.subjectBacteriaen_US
dc.subjectCase-control studiesen_US
dc.subjectCell polarityen_US
dc.subjectCohort studiesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMicrobiotaen_US
dc.subjectMiddle Ageden_US
dc.subjectPsoriasisen_US
dc.subjectSkinen_US
dc.subjectTh17 cellsen_US
dc.subjectYoung adulten_US
dc.titleAlteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarizationen_US
dc.titleAlteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
Ä°sim:
Alteration of the cutaneous microbiome in.pdf
Boyut:
3.18 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
Ä°ndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
Ä°sim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
Ä°ndir

Koleksiyon

Dahili Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu