Comparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter Backbone-1 Study

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dc.contributor.authorErdem, Hakan
dc.contributor.authorElaldi, Nazif
dc.contributor.authorBatirel, Ayse
dc.contributor.authorAliyu, Sani
dc.contributor.authorSengoz, Gonul
dc.contributor.authorPehlivanoglu, Filiz
dc.contributor.authorRamosaco, Ergys
dc.date.accessioned2024-04-24T16:18:23Z
dc.date.available2024-04-24T16:18:23Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND CONTEXT: No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature. PURPOSE: This study aimed to compare directly the clinical features, laboratory and radiological aspects, treatment, and outcome data of patients diagnosed as BSD and TSD. STUDY DESIGN: A retrospective, multinational, and multicenter study was used. PATIENT SAMPLE: A total of 641 (TSD, 314 and BSD, 327) spondylodiscitis patients from 35 different centers in four countries (Turkey, Egypt, Albania, and Greece) were included. OUTCOME MEASURES: The pre- and peri- or post-treatment spinal deformity and neurologic deficit parameters, and mortality were carried out. METHODS: Brucellar spondylodiscitis and TSD groups were compared for demographics, clinical, laboratory, radiological, surgical interventions, treatment, and outcome data. The Student t test and Mann-Whitney U test were used for group comparisons. Significance was analyzed as two sided and inferred at 0.05 levels. RESULTS: The median baseline laboratory parameters including white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were higher in TSD than BSD (p<.0001). Prevertebral, paravertebral, epidural, and psoas abscess formations along with loss of vertebral corpus height and calcification were significantly more frequent in TSD compared with BSD (p<.01). Surgical interventions and percutaneous sampling or abscess drainage were applied more frequently in TSD (p<.0001). Spinal complications including gibbus deformity, kyphosis, and scoliosis, and the number of spinal neurologic deficits, including loss of sensation, motor weakness, and paralysis were significantly higher in the TSD group (p<.05). Mortality rate was 2.22% (7 patients) in TSD, and it was 0.61% (2 patients) in the BSD group (p=.1). CONCLUSIONS: The results of this study show that TSD is a more suppurative disease with abscess formation requiring surgical intervention and characterized with spinal complications. We propose that using a constellation of constitutional symptoms (fever, back pain, and weight loss), pulmonary involvement, high inflammatory markers, and radiological findings will help to differentiate between TSD and BSD at an early stage before microbiological results are available. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.spinee.2015.09.024
dc.identifier.endpage2517en_US
dc.identifier.issn1529-9430
dc.identifier.issn1878-1632
dc.identifier.issue12en_US
dc.identifier.pmid26386176
dc.identifier.scopus2-s2.0-84964434615
dc.identifier.scopusqualityQ1
dc.identifier.startpage2509en_US
dc.identifier.urihttps://doi.org/10.1016/j.spinee.2015.09.024
dc.identifier.urihttps://hdl.handle.net/11468/16054
dc.identifier.volume15en_US
dc.identifier.wosWOS:000366655100045
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofSpine Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrucellosisen_US
dc.subjectComplicationen_US
dc.subjectOutcomeen_US
dc.subjectSequelaeen_US
dc.subjectSpondylodiscitisen_US
dc.subjectTuberculosisen_US
dc.titleComparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter Backbone-1 Studyen_US
dc.titleComparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter Backbone-1 Study
dc.typeArticleen_US

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