Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods

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dc.authorid0000-0002-6536-4185en_US
dc.authorid0000-0003-4551-8439en_US
dc.contributor.authorNacir, Mustafa
dc.contributor.authorİbiloğlu, İbrahim
dc.contributor.authorAlabalık, Ulaş
dc.date.accessioned2024-04-15T12:43:46Z
dc.date.available2024-04-15T12:43:46Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractThyroid neoplasms are the most common endocrine malignancies. ZIP4 is an intramembranous zinc trans membrane protein. Zinc plays a central role in the activation of transcription factors, and zinc transporters. This affects tumour migration, invasion, and cell proliferation. ZO-1 and Claudin-1 are important tight junction proteins whose amounts increase and decrease in various cancers. In this study, we aimed to investigate the expression of ZIP4, ZO-1, and Claudin-1 in thyroid tumours and the relationship of this expression with tumour types and prognostic parameters. ZIP4, ZO-1, and Claudin-1 were studied in all cases by immunohistochemical and Real-Time PCR methods. ZIP4 and Claudin-1 tended to be expressed more in cases with tumours, while ZO-1 in cases with and without tumours. Expression of ZIP4 and Claudin-1 by real-time polymerase chain reaction showed a significant difference between histological subtypes, and this difference was not observed with ZO-1. It was observed that the presence of metastasis increased with the expression of ZIP4 and Claudin-1, and there was no significant change with ZO-1. We think that Claudin-1 and ZIP4 expression can be used as an important marker in terms of showing poor prognosis and susceptibility to metastasis in thyroid tumours, and in developing targeted therapy.en_US
dc.identifier.citationNacir, M., İbiloğlu, İ. ve Alabalık, U. (2023). Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods. Polish Journal of Pathology, 74(4), 248-255.en_US
dc.identifier.doi10.5114/pjp.2023.134318
dc.identifier.endpage255en_US
dc.identifier.issn1233-9687
dc.identifier.issue4en_US
dc.identifier.pmid38477086
dc.identifier.scopus2-s2.0-85184707499
dc.identifier.scopusqualityQ4
dc.identifier.startpage248en_US
dc.identifier.urihttps://www.termedia.pl/Investigation-of-ZIP4-ZO-1-and-CLAUDIN-1-expression-in-thyroid-tumours-by-immunohistochemistry-and-real-time-polymerase-chain-reaction-methods,55,52240,1,1.html
dc.identifier.urihttps://hdl.handle.net/11468/13874
dc.identifier.volume74en_US
dc.identifier.wosWOS:001157871200002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİbiloğlu, İbrahim
dc.institutionauthorAlabalık, Ulaş
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofPolish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClaudin-1en_US
dc.subjectThyroid carcinomaen_US
dc.subjectZIP4en_US
dc.subjectZO-1en_US
dc.titleInvestigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methodsen_US
dc.titleInvestigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods
dc.typeArticleen_US

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