The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

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dc.authorid0000-0003-1944-2477en_US
dc.authorid0000-0003-2774-8601en_US
dc.authorid0000-0003-1944-2477en_US
dc.authorid0000-0001-9912-7340en_US
dc.contributor.authorElik, Dilşah Başkol
dc.contributor.authorKaya, Şafak
dc.contributor.authorAlkan, Sevil
dc.contributor.authorDemirdal, Tuna
dc.contributor.authorŞener, Alper
dc.contributor.authorKaya, Selçuk
dc.contributor.authorTunçcan, Özlem Güzel
dc.contributor.authorMermutluoğlu, Çiğdem
dc.date.accessioned2024-04-18T12:50:10Z
dc.date.available2024-04-18T12:50:10Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractThis multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020–15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639–16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137–20.172), the need for mechanical ventilation (p < 0.001, OR 62.042, 95% CI 9.528–404.011); (iii) need for mechanical ventilation: failure to recover from neutropenia (p < 0.001, OR 17.869, 95% CI 3.592–88.907), receiving tocilizumab therapy (p = 0.028, OR 32.227, 95% CI 1.469–707.053), septic shock (p = 0.001, OR 15.4 96% CI 3.164–75.897), and the need for ICU (p < 0.001, OR 91.818, 95% CI 15.360–548.873), (iv) OMM: [mechanical ventilation (p = 0.001, OR 19.041, 95% CI 3.229–112.286) and septic shock (p = 0.010, OR 5.589,95% CI 1.509–20.700)]. Although it includes a relatively limited number of patients, our findings suggest that COVID-19 and FEN are associated with significant mortality and morbidity.en_US
dc.identifier.citationElik, D. B., Kaya, Ş., Alkan, S., Demirdal, T., Şener, A., Kaya, S. ve diğerleri. (2024). The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study. Scientific Reports, 14(1), 1-12.en_US
dc.identifier.doi10.1038/s41598-024-55886-w
dc.identifier.endpage12en_US
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid38433274
dc.identifier.scopus2-s2.0-85186610412
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.nature.com/articles/s41598-024-55886-w
dc.identifier.urihttps://hdl.handle.net/11468/13928
dc.identifier.volume14en_US
dc.identifier.wosWOS:001184650000016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMermutluoğlu, Çiğdem
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronavirus diseaseen_US
dc.subjectTreatmenten_US
dc.subjectPrognosisen_US
dc.titleThe clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos studyen_US
dc.titleThe clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study
dc.typeArticleen_US

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