Protective effects of L-glutamine against toxicity of deltamethrin in the cerebral tissue

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dc.contributor.authorVarol, Sefer
dc.contributor.authorOzdemir, Hasan Huseyin
dc.contributor.authorCevik, Mehmet Ugur
dc.contributor.authorAltun, Yasar
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorEkinci, Aysun
dc.contributor.authorIbiloglu, Aslihan Okan
dc.date.accessioned2024-04-24T17:18:28Z
dc.date.available2024-04-24T17:18:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Deltamethrin (DLM) is a broad-spectrum synthetic dibromo-pyrethroid pesticide that is widely used for agricultural and veterinary purposes. However, human exposure to the pesticide leads to neurotoxicity. Glutamine is one of the principal, free intracellular amino acids and may also be an antioxidant. This study was undertaken in order to examine the neuroprotective and antioxidant potential of L-glutamine against DLM toxicity in female Wistar albino rats. Materials and methods: The rats were divided into the following groups (n=10): Group I: control (distilled water; 10 mL/kg, po one dose), Group II: L-glutamine (1.5 g/kg, po one dose), Group III: DLM (35 mg/kg, po one dose), and Group IV: DLM (35 mg/kg, po one dose) and L-glutamine (1.5 g/kg, po one dose after 4 hours). Total oxidant status (TOS), total antioxidant status (TAS), tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 levels and apoptosis were evaluated in brain tissue. Results: DLM-treated animals had a significant increase in brain biochemical parameters, as well as TOS and TAS. Furthermore, the histopathological examination showed neuronal cell degeneration in the cerebral tissue. L-Glutamine treatment decreased the elevated brain levels of TOS and neuronal cell degeneration. There was no difference in tumor necrosis factor-a, IL-1 beta, and IL-6 levels between the groups. Conclusion: L-Glutamine may reduce the toxic effects of DLM in the cerebral tissue through antioxidant properties.en_US
dc.identifier.doi10.2147/NDT.S104011
dc.identifier.endpage1011en_US
dc.identifier.issn1178-2021
dc.identifier.pmid27143900
dc.identifier.scopus2-s2.0-84966769111
dc.identifier.scopusqualityQ2
dc.identifier.startpage1005en_US
dc.identifier.urihttps://doi.org/10.2147/NDT.S104011
dc.identifier.urihttps://hdl.handle.net/11468/18792
dc.identifier.volume12en_US
dc.identifier.wosWOS:000374500400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeltamethrinen_US
dc.subjectL-Glutamineen_US
dc.subjectRaten_US
dc.titleProtective effects of L-glutamine against toxicity of deltamethrin in the cerebral tissueen_US
dc.titleProtective effects of L-glutamine against toxicity of deltamethrin in the cerebral tissue
dc.typeArticleen_US

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