Potentiation of cisplatin-induced nephrotoxicity in rats by allopurinol

Basit Öğe Kaydı
dc.contributor.authorErdinç, M
dc.contributor.authorErdinç, L
dc.contributor.authorNergiz, Y
dc.contributor.authorIsik, B
dc.date.accessioned2024-04-24T17:37:47Z
dc.date.available2024-04-24T17:37:47Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractCisplatin (CDDP) is an effective chemotherapeutic agent used against various human malignancies. However, it induces nephrotoxicity, a severe side effect in which oxygen free radicals have been implicated to play an important role. The effect of allopurinol (Allp) given in a dose of 50 mg/kg su:,cutaneously (sc) for five days was examined on induced nephrotoxicity by a single dose of 5 mg/kg CDDP intraperitoneally (ip) in male wistar rats. Serum creatinine and blood urea nitrogen (BUN) concentrations were found significantly higher in the group given both Allp and CDDP than in the group given CDDP alone, p < 0.001, rind histopathological examination showed more excessive degree of proximal tubular necrosis in the kidneys of animals given CDDP plus Allp than in those treated with CDDP alone. Increased renal lipid peroxidation, p < 0.001 associated with these pathological alterations suggested that oxidative stress may be involved in the potential:ion of CDDP-induced nephrotoxicity by Allp.en_US
dc.identifier.endpage334en_US
dc.identifier.issn0940-2993
dc.identifier.issue4en_US
dc.identifier.pmid10987186
dc.identifier.scopus2-s2.0-0033841719
dc.identifier.scopusqualityN/A
dc.identifier.startpage329en_US
dc.identifier.urihttps://hdl.handle.net/11468/21183
dc.identifier.volume52en_US
dc.identifier.wosWOS:000089159900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUrban & Fischer Verlagen_US
dc.relation.ispartofExperimental and Toxicologic Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectNephrotoxicityen_US
dc.subjectAllopurinolen_US
dc.subjectLipid Peroxidationen_US
dc.titlePotentiation of cisplatin-induced nephrotoxicity in rats by allopurinolen_US
dc.titlePotentiation of cisplatin-induced nephrotoxicity in rats by allopurinol
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu