An investigation of the effect of placental growth factor on intrapartum fetal compromise prediction in term-induced high risk pregnancies

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dc.contributor.authorBudak, Mehmet Sukru
dc.contributor.authorToprak, Gulten
dc.contributor.authorAkgol, Sedat
dc.contributor.authorObut, Mehmet
dc.contributor.authorOglak, Cemil
dc.contributor.authorBagli, Ihsan
dc.contributor.authorKahramanoglu, Ilker
dc.date.accessioned2024-04-24T17:27:57Z
dc.date.available2024-04-24T17:27:57Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To date, there is no available test to predict the risk of intrapartum fetal compromise (IFC) during labor, either starting spontaneously or induced due to obstetrics indications. The aim of this study was to examine the effectiveness of placental growth factor (PIGF) in identifying cases that develop intrapartum fetal compromise (IFC) in term high-risk pregnancies induced for labor. Material and methods: This prospective cross-sectional study was conducted on 40 IFC+ cases and 40 IFC- cases with high-risk term pregnancy and labor induction started in the Health Sciences University Gazi Yasargil Training and Research Hospital, between January 2018 and April 2018. Comparisons were made between the groups in respect of placental growth factor (PIGF) levels, and obstetric and neonatal outcomes. Results: The PIGF level was found to be statistically significantly lower in the IFC+ cases compared to the IFC- cases. For a PIGF cutoff value of 32 pg/mL for the prediction of IFC+ cases, sensitivity was 74.4%, specificity 73.2%, NPV 75% and PPV 72.5%, with a statistically significant difference determined between the groups. The IFC+ development risk increased 7.91-fold in patients with PIGF <= 32 pg/mL. Conclusions: The PIGF levels in cases of IFC+ high risk pregnancies were found to be statistically significantly lower than those of IFC-cases. However, further, large-scale randomized controlled research is necessary to demonstrate this relationship better.en_US
dc.identifier.doi10.5603/GP.a2018.0118
dc.identifier.endpage704en_US
dc.identifier.issn0017-0011
dc.identifier.issn2543-6767
dc.identifier.issue12en_US
dc.identifier.pmid30618039
dc.identifier.scopus2-s2.0-85059373161
dc.identifier.scopusqualityQ3
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.5603/GP.a2018.0118
dc.identifier.urihttps://hdl.handle.net/11468/20265
dc.identifier.volume89en_US
dc.identifier.wosWOS:000455400500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTerm High-Risk Pregnancyen_US
dc.subjectLabor Inductionen_US
dc.subjectPlacental Growth Factoren_US
dc.subjectIntrapartum Fetal Compromiseen_US
dc.titleAn investigation of the effect of placental growth factor on intrapartum fetal compromise prediction in term-induced high risk pregnanciesen_US
dc.titleAn investigation of the effect of placental growth factor on intrapartum fetal compromise prediction in term-induced high risk pregnancies
dc.typeArticleen_US

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