Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey

Basit Öğe Kaydı
dc.contributor.authorEl-Sokkary, Rehab
dc.contributor.authorUysal, Serhat
dc.contributor.authorErdem, Hakan
dc.contributor.authorKullar, Ravina
dc.contributor.authorPekok, Abdullah Umut
dc.contributor.authorAmer, Fatma
dc.contributor.authorGrgic, Svjetlana
dc.date.accessioned2024-04-24T16:02:02Z
dc.date.available2024-04-24T16:02:02Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractEvaluating trends in antibiotic resistance is a requisite. The study aimed to analyze the profile of multidrug-resistant organisms (MDROs) among hospitalized patients with bacteremia in intensive care units (ICUs) in a large geographical area. This is a 1-month cross-sectional survey for blood-borne pathogens in 57 ICUs from 24 countries with different income levels: lower-middle-income (LMI), upper-middle-income (UMI), and high-income (HI) countries. Multidrug-resistant (MDR), extensively drug-resistant (XDR), or pan-drug-resistant isolates were searched. Logistic regression analysis determined resistance predictors among MDROs. Community-acquired infections were comparable to hospital-acquired infections particularly in LMI (94/202; 46.5% vs 108/202; 53.5%). Although MDR (65.1%; 502/771) and XDR (4.9%; 38/771) were common, no pan-drug-resistant isolate was recovered. In total, 32.1% of MDR were Klebsiella pneumoniae, and 55.3% of XDR were Acinetobacter baumannii. The highest MDR and XDR rates were in UMI and LMI, respectively, with no XDR revealed from HI. Predictors of MDR acquisition were male gender (OR, 12.11; 95% CI, 3.025-15.585) and the hospital-acquired origin of bacteremia (OR, 2.643; 95%CI, 1.462-3.894), and XDR acquisition was due to bacteremia in UMI (OR, 3.344; 95%CI, 1.189-5.626) and admission to medical-surgical ICUs (OR, 1.481; 95% CI, 1.076-2.037). We confirm the urgent need to expand stewardship activities to community settings especially in LMI, with more paid attention to the drugs with a higher potential for resistance. Empowering microbiology laboratories and reports to direct prescribing decisions should be prioritized. Supporting stewardship in ICUs, the mixed medical-surgical ones in particular, is warranted.en_US
dc.identifier.doi10.1007/s10096-021-04288-1
dc.identifier.endpage2334en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue11en_US
dc.identifier.pmid34155547
dc.identifier.scopus2-s2.0-85117479837
dc.identifier.scopusqualityQ1
dc.identifier.startpage2323en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-021-04288-1
dc.identifier.urihttps://hdl.handle.net/11468/14584
dc.identifier.volume40en_US
dc.identifier.wosWOS:000664017300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultidrug Resistanceen_US
dc.subjectInfection Controlen_US
dc.subjectStewardshipen_US
dc.subjectLow- And Upper-Middle And High Incomeen_US
dc.subjectXdren_US
dc.subjectPan-Drug Resistanceen_US
dc.titleProfiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI surveyen_US
dc.titleProfiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu