Effect of hyperbaric oxygen therapy on healing in an experimental model of degloving injury in tails of nicotine-treated rats

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dc.contributor.authorDemirtas, A.
dc.contributor.authorAzboy, I.
dc.contributor.authorBulut, M.
dc.contributor.authorUcar, B. Y.
dc.contributor.authorAlabalik, U.
dc.contributor.authorIlgezdi, S.
dc.date.accessioned2024-04-24T17:14:45Z
dc.date.available2024-04-24T17:14:45Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on healing in an experimental model of a degloving injury of the tails of nicotine-treated rats. Thirty-two male Sprague-Dawley rats were randomized to four groups (n = 8): nicotine (group 1); HBO (group 2); nicotine + HBO (group 3); and control (group 4). The mean length of the necrotic parts of the tails at the degloving injury site was significantly higher in group 1 compared with groups 2, 3, and 4, and was significantly lower in group 2 compared with groups 1, 3, and 4. The mean histopathological stage of ulcers at the degloving injury site was statistically significantly higher (more severe) in group 1 compared with groups 2, 3, and 4, and was statistically significantly lower in group 2 compared with groups 1, 3, and 4. It appears that the negative effects of nicotine on wound healing in degloving injuries are negated by the positive effects of immediate HBO therapy.en_US
dc.identifier.doi10.1177/1753193412469130
dc.identifier.endpage411en_US
dc.identifier.issn1753-1934
dc.identifier.issn2043-6289
dc.identifier.issue4en_US
dc.identifier.pmid23221280
dc.identifier.scopus2-s2.0-84876722176
dc.identifier.scopusqualityQ2
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1177/1753193412469130
dc.identifier.urihttps://hdl.handle.net/11468/18177
dc.identifier.volume38Een_US
dc.identifier.wosWOS:000317930900011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Hand Surgery-European Volume
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDeglovingen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectNicotineen_US
dc.subjectWound Healingen_US
dc.titleEffect of hyperbaric oxygen therapy on healing in an experimental model of degloving injury in tails of nicotine-treated ratsen_US
dc.titleEffect of hyperbaric oxygen therapy on healing in an experimental model of degloving injury in tails of nicotine-treated rats
dc.typeArticleen_US

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