Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury

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dc.contributor.authorSen, Velat
dc.contributor.authorGuzel, Abdulmenap
dc.contributor.authorSen, Hadice Selimoglu
dc.contributor.authorEce, Aydin
dc.contributor.authorUluca, Unal
dc.contributor.authorSoker, Sevda
dc.contributor.authorDogan, Erdal
dc.date.accessioned2024-04-24T17:12:13Z
dc.date.available2024-04-24T17:12:13Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model. Twenty-eight male Wistar albino rats weighing 300-350 g were allocated randomly to four groups. In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontaneously. In group 2, rats received standard ventilation (SV) in addition to NS. In group 3, hydrochloric acid was injected into the lungs and rats received SV. In group 4, rats received SV and 100 mu g/kg intraperitoneal dexmedetomidine before intratracheal HCl instillation. Blood samples and liver tissue specimens were examined by biochemical, histopathological, and immunohistochemical methods. Acute lung injury (ALI) was found to be associated with increased malondialdehyde (MDA), total oxidant activity (TOA), oxidative stress index (OSI), and decreased total antioxidant capacity (TAC). Significantly decreased MDA, TOA, and OSI levels and significantly increased TAC levels were found with dexmedetomidine injection in group 4 (P < 0.05). The highest histologic injury scores were detected in group 3. Enhanced hepatic vascular endothelial growth factor (VEGF) expression and reduced CD68 expression were found in dexmedetomidine group compared with the group 3. In conclusion, the presented data provide the first evidence that dexmedetomidine has a protective effect on experimental liver injury induced by ALI.en_US
dc.description.sponsorshipDUBAP (Dicle University coordination committee of scientific research projects)en_US
dc.description.sponsorshipThe authors thank DUBAP (Dicle University coordination committee of scientific research projects) for scientific and financial support.en_US
dc.identifier.doi10.1155/2014/621827
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid25165710
dc.identifier.scopus2-s2.0-84929057194
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2014/621827
dc.identifier.urihttps://hdl.handle.net/11468/17894
dc.identifier.volume2014en_US
dc.identifier.wosWOS:000340382700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titlePreventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injuryen_US
dc.titlePreventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury
dc.typeArticleen_US

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