Hereditary Thrombophilic Factors in Stroke Due to Cerebral Infarct

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dc.contributor.authorBolaman, Zahit
dc.contributor.authorOzkul, Ayca
dc.contributor.authorKiylioglu, Nefati
dc.contributor.authorKadikoylu, Gurhan
dc.contributor.authorErturk, Ahmet
dc.contributor.authorBatun, Sabri
dc.contributor.authorAkyol, Ali
dc.date.accessioned2024-04-24T17:08:18Z
dc.date.available2024-04-24T17:08:18Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The stroke is the third most common cause of all deaths. In new Studies, the importance of hereditary thrombophilic factors on stroke is emphasized. The aim of this study is to determine the role of hereditary thrombophilic factors including factor V Leiden A1691G (FVL), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations in patients with stroke because of cerebral infarct. Methods: Twenty-four patients with stroke and 53 controls with risk factor for stroke were enrolled. Polymerase chain reaction was used to detect these mutations. Results: Heterozygote FVL mutation in 2 (8.3%) patients and MTHFR mutation in 10 (41.7%) patients were detected. In the control group, there were 2 (3.9%) patients with heterozygote FVL mutation and 15 (28.3%) patients with MTHR mutation. Both FVL and MTHFR gene Mutations were detected in I patient and 2 controls, respectively. Prothrombin gene mutation was not found in 2 groups. There were not statistically significant differences for all 3 mutation,; in-between 2 groups (P > 0.05). Odds ratios were 0.431 (0.074 2.504, 95% CI) for FVL mutation and 0.553 (0.221 1.381, 95% CI) for MTHFR mutation, respectively. Conclusion: Although our study group was small, hereditary thrombophilic factors might not be risk factors for stroke because of cerebral infarct.en_US
dc.identifier.doi10.1097/MAJ.0b013e3181753b86
dc.identifier.endpage13en_US
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue1en_US
dc.identifier.pmid19263510
dc.identifier.scopus2-s2.0-62249195567
dc.identifier.scopusqualityQ1
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1097/MAJ.0b013e3181753b86
dc.identifier.urihttps://hdl.handle.net/11468/17292
dc.identifier.volume337en_US
dc.identifier.wosWOS:000262872700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal of The Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebral Infarcten_US
dc.subjectHereditaryen_US
dc.subjectThrombophilic Factorsen_US
dc.subjectStrokeen_US
dc.titleHereditary Thrombophilic Factors in Stroke Due to Cerebral Infarcten_US
dc.titleHereditary Thrombophilic Factors in Stroke Due to Cerebral Infarct
dc.typeArticleen_US

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