Potential biomarkers for the early detection of acute kidney injury after percutaneous nephrolithotripsy

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dc.contributor.authorDaggulli, Mansur
dc.contributor.authorUtangac, Mehmet M.
dc.contributor.authorDede, Onur
dc.contributor.authorBodakci, Mehmet N.
dc.contributor.authorHatipoglu, Namik K.
dc.contributor.authorPenbegül, Necmettin
dc.contributor.authorSancaktutar, Ahmet Ali
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aims to investigate the role of urinary biomarkers in the determination of the potential risks of renal parenchymal tubular damage in adult patients who underwent percutaneous nephrolithotomy (PNL) with the indication of renal stone. A randomized and prospective controlled study was performed between June and December 2013. We enrolled 29 consecutive patients with renal calculi>2cm and who underwent PNL, as well as 47 healthy control subjects. Urine samples, including 2 h before surgery, 2 and 24 h after surgery were collected from the patient group. Freshly voided urine samples were collected from the control group. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-glucosaminidase (NAG), and liver-type fatty acid binding protein (LFABP) levels were measured from these urine samples. The mean KIM-1/Cr value that measured 24 h after the operation was statistically significant, higher than its preoperative (preop) level (p= 0.045). A significant difference was detected between the mean preop and postoperative (postop) 24 h NAG/Cr values (p< 0.001). Also, postop 24 h NGAL/Cr levels were statistically significant, higher than its preop levels (p= 0.013). According to the comparison of preop and postop levels, an increase in LFABP/Cr values secondary to surgical intervention was observed without any statistically significant difference. Besides the LFABP/Cr levels do not change after percutaneous kidney surgery, KIM-1/Cr, NAG/Cr, and NGAL/Cr levels increase postop period, especially at 24 h. Further studies with a larger series and repeated measurements should be performed to clarify if they can be used to demonstrate renal damage after percutaneous surgery or not.en_US
dc.identifier.doi10.3109/0886022X.2015.1073494
dc.identifier.endpage156en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid26481764
dc.identifier.scopus2-s2.0-84955655759
dc.identifier.scopusqualityQ2
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1073494
dc.identifier.urihttps://hdl.handle.net/11468/19072
dc.identifier.volume38en_US
dc.identifier.wosWOS:000368809300024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPnlen_US
dc.subjectUrinary Biomarkersen_US
dc.subjectKim-1en_US
dc.subjectRenal Stoneen_US
dc.subjectAkien_US
dc.titlePotential biomarkers for the early detection of acute kidney injury after percutaneous nephrolithotripsyen_US
dc.titlePotential biomarkers for the early detection of acute kidney injury after percutaneous nephrolithotripsy
dc.typeArticleen_US

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