Anti-oxidant status in relation to lipoproteins, leptin and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndrome

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dc.contributor.authorEce, A
dc.contributor.authorAtamer, Y
dc.contributor.authorGürkan, F
dc.contributor.authorBilici, M
dc.contributor.authorKoçyigit, Y
dc.date.accessioned2024-04-24T17:11:32Z
dc.date.available2024-04-24T17:11:32Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Reactive oxygen species and cytokines are reported to play a role in the proteinuria of nephrotic syndrome. The aim of this study was to investigate indirect evidence of oxidant activity together with leptin, lipoproteins and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndrome. Methods: A total of 40 children with steroid-sensitive nephrotic syndrome (20 with newly onset or relapse comprised group I and 20 in remission while receiving steroids comprised group II) and 20 sex and age matched healthy control children were included. The following indirect parameters of oxidant activity were determined: serum malondialdehyde, erythrocyte superoxide dismutase, catalase and whole-blood-reduced glutathione. Serum leptin, lipids and lipoproteins were also determined. Results: Similar glutathione, increased malondialdehyde levels and decreased superoxide dismutase and catalase activity were observed in group I patients compared with controls. There was no significant difference in these variables between group I and group II (P > 0.05). Tumour necrosis factor-alpha and interleukin-6 concentrations were similar in patients and controls. Concentrations of interleukin-1beta and interleukin-8 were higher in the active phase of nephrotics compared with controls (P < 0.05). Significant positive correlations were found between malondialdehyde and interleukin-1beta, interleukin-6, leptin and lipoprotein (a) (P < 0.05). There were significant negative correlations between anti-oxidants and leptin, lipoprotein (a) and several cytokines (P < 0.05). Conclusions: Changes in the concentrations of malondialdehyde, superoxide dismutase, catalase and glutathione are compatible with increased amounts of oxidation in steroid-sensitive nephrotic syndrome. Leptin and pro-inflammatory cytokines may be related to excessive protein permeability in nephrotic syndrome.en_US
dc.identifier.doi10.1111/j.1440-1797.2004.00340.x
dc.identifier.endpage373en_US
dc.identifier.issn1320-5358
dc.identifier.issue6en_US
dc.identifier.pmid15663638
dc.identifier.scopus2-s2.0-12244257550
dc.identifier.scopusqualityQ2
dc.identifier.startpage366en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1797.2004.00340.x
dc.identifier.urihttps://hdl.handle.net/11468/17589
dc.identifier.volume9en_US
dc.identifier.wosWOS:000225792500006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBlackwell Publishing Asiaen_US
dc.relation.ispartofNephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Oxidantsen_US
dc.subjectChildrenen_US
dc.subjectCytokinesen_US
dc.subjectLipoproteinsen_US
dc.subjectNephrotic Syndromeen_US
dc.titleAnti-oxidant status in relation to lipoproteins, leptin and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndromeen_US
dc.titleAnti-oxidant status in relation to lipoproteins, leptin and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndrome
dc.typeArticleen_US

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