Evaluation of spatial memory and locomotor activity during hypercortisolism induced by the administration of dexamethasone in adult male rats

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dc.contributor.authorYilmaz, Teufik
dc.contributor.authorGedikli, Oznur
dc.contributor.authorYildirim, Mehmet
dc.date.accessioned2024-04-24T16:10:57Z
dc.date.available2024-04-24T16:10:57Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn neurosurgery practice glucocorticoids are commonly used. Steroids may have central nervous system side effects affecting whole body, including steroid-induced mental agitation and psychosis. In experimental and clinical studies conducted by using dexamethasone (DEX), it has been reported that DEX adversely affects learning and memory skills. Unfortunately, there are yet no clinically accepted clinical approaches to prevent DEX-induced cognitive dysfunction. In this experimental study it was aimed to investigate the effect of chronic DEX administration on learning-memory and locomotor behaviors in adult male Sprague Dawley rats. In addition, it was also aimed to explore the potential favorable contribution of melatonin (MEL) and vitamin C (Vit C) having antioxidant and neuroprotective properties to the effects of DEX on learning-memory and locomotor behaviors. For this purpose, rats were injected 10 mg/kg DEX intraperitoneally, both alone and in combination with MEL (40 mg/kg) and Vit C (100 mg/kg), for 9 days, and the animals were tested using the radial arm maze and open field apparatus. The test results revealed that DEX caused a significant decrease in spatial memory and locomotor activities and MEL and Vit C failed to reverse losses in these activities. Furthermore, DEX led to a gradual weight loss that reached 30% of the initial weight at 9th day of the injection. DEX administration causes a generalized loss of behavioral activity of rats. Experimental studies devised to investigate effects of DEX should take into account this DEX-induced generalized behavioral loss when assessing the effects of DEX on learning and memory skills. This article is part of a Special Issue entitled SI: Brain and Memory. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2014.04.034
dc.identifier.endpage50en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid24796878
dc.identifier.scopus2-s2.0-84920047207
dc.identifier.scopusqualityQ2
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2014.04.034
dc.identifier.urihttps://hdl.handle.net/11468/15201
dc.identifier.volume1595en_US
dc.identifier.wosWOS:000349197600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexamethasoneen_US
dc.subjectMelatoninen_US
dc.subjectVitamin Cen_US
dc.subjectMemoryen_US
dc.subjectLocomotor Activityen_US
dc.subjectRaten_US
dc.titleEvaluation of spatial memory and locomotor activity during hypercortisolism induced by the administration of dexamethasone in adult male ratsen_US
dc.titleEvaluation of spatial memory and locomotor activity during hypercortisolism induced by the administration of dexamethasone in adult male rats
dc.typeReview Articleen_US

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