Role of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats

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dc.contributor.authorBilgin, H. M.
dc.contributor.authorTumer, C.
dc.contributor.authorDiken, H.
dc.contributor.authorKelle, M.
dc.contributor.authorSermet, A.
dc.date.accessioned2024-04-24T17:20:48Z
dc.date.available2024-04-24T17:20:48Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractGhrelin, an endogenous ligand for growth hormone secretagogue receptor (GHS-R), has been identified in the rat and human gastrointestinal tract. Ghrelin has been proposed to play a role in gastric acid secretion. Nitric oxide (NO) was shown as a mediator in the mechanism of ghrelin action on gastric acid secretory function. However, there is a little knowledge about this topic. We have investigated the role of ghrelin in gastric acid secretion and the role of NO as a mediator. Wistar albino rats were used in this study. The pyloric sphincter was ligated through a small midline incision. By the time, saline (0.5 ml, iv) was injected to the control group, ghrelin (20 mu g/kg, iv) was injected to the first experimental group, ghrelin (20 mu g/kg, iv) + L-NAME (70 mg/kg, sc) was injected to the second group and L-NAME (70 mg/kg, sc) was administered to the third group. The rats were killed 3 h after pylorus ligation; gastric acid secretion, mucus content and plasma nitrite levels were measured. Exogenous ghrelin administration increased gastric acid output, mucus content and total plasma nitrite levels, while these effects of ghrelin were inhibited by applying L-NAME. We can conclude that ghrelin participates in the regulation of gastric acid secretion through NO as a mediator.en_US
dc.identifier.doi10.33549/physiolres.931234
dc.identifier.endpage568en_US
dc.identifier.issn0862-8408
dc.identifier.issn1802-9973
dc.identifier.issue4en_US
dc.identifier.pmid17705669
dc.identifier.scopus2-s2.0-50449096217
dc.identifier.scopusqualityQ3
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.33549/physiolres.931234
dc.identifier.urihttps://hdl.handle.net/11468/19257
dc.identifier.volume57en_US
dc.identifier.wosWOS:000259157300009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAcad Sciences Czech Republic, Inst Physiologyen_US
dc.relation.ispartofPhysiological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGhrelinen_US
dc.subjectAcid Secretionen_US
dc.subjectNitric Oxideen_US
dc.subjectRaten_US
dc.titleRole of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in ratsen_US
dc.titleRole of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats
dc.typeArticleen_US

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