Effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury

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dc.contributor.authorTurgut, Fethiye Gülden
dc.contributor.authorÖzevren, Hüseyin
dc.contributor.authorYıldırım, M.
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:58:18Z
dc.date.available2024-04-24T17:58:18Z
dc.date.issued2018
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractHead trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group was head-traumatized group (n=10) and last group was head-traumatized+Caffeic acid phenethyl ester (CAPE, i.p. 20ml/kg/day). Upon head was traumatized, CAPE was applied to trauma+CAPE group and then for the following four days. At the end of 5th day, rats were anesthetized with ketamine hydroxide and then blood samples were taken for biochemical analysis. MDA and GSH-Px values were compared. After blood sample, total eyes of rats were dissected for histopathological and immunohistochemical analysis. In trauma group, degeneration in retinal photoreceptor cells, disintegrity and in inner and outer nuclear layers, hypertrophy in ganglion cells, and hemorrhage in blood vessels were observed. In the group treated with CAPE, lesser degeneration in photoreceptor cells, regular appearances of inner and outer nuclear layers, mild hemorrhage in blood vessels of ganglionic cell layer were observed. The apoptotic changes caused by trauma seen in photoreceptor and ganglionic cells were decreased and cellular organization was preserved due to CAPE treatment. CAPE was thought to induce healing process on traumatic damages.en_US
dc.identifier.citationTurgut, F. G., Özevren, H., Yıldırım, M. ve Deveci, E. (2018). Effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury. International Journal of Morphology, 36(1), 97-103.
dc.identifier.doi10.4067/S0717-95022018000100097
dc.identifier.endpage103en_US
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85044571045en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022018000100097
dc.identifier.urihttps://hdl.handle.net/11468/23824
dc.identifier.volume36en_US
dc.identifier.wosWoSidYok
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeic Acid Phenethyl Ester (Cape)en_US
dc.subjectRaten_US
dc.subjectRetinaen_US
dc.subjectTraumatic Brain İnjuryen_US
dc.titleEffects of caffeic acid phenethyl ester on retinal damage after traumatic brain injuryen_US
dc.title.alternativeEfectos del ester fenetílico del ácido cafeico en el daño de la retina después de una lesion cerebral traumáticaen_US
dc.typeArticleen_US

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