Biochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissue

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dc.contributor.authorToprak, Veysel
dc.contributor.authorAkalın, Senem Alkan
dc.contributor.authorÖcal, Ece
dc.contributor.authorÇavuş, Yunus
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:56:46Z
dc.date.available2024-04-24T17:56:46Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: It was aimed to investigate the biochemical and immunohistochemical effects of ephedrine (EPH) in bilateral ovariectomized rats. Methods: Twenty-four Sprague Dawley female rats were divided into three groups: control group: The abdomen was opened and closed without any treatment; ischemia-reperfusion (IR) group: 2 h of ischemia followed by 2 h of reperfusion were allowed to cause IR injury; IR+EPH group: oral EPH solution (5 mg/kg) was administered for 28 days. Results: Biochemical parameters were statistically significant in group comparisons. Increased interleukin-6 (IL-6) expression, degenerative preantral and antral follicle cells and inflammatory cells around blood vessels were seen in IR group. Negative IL-6 expression was observed in seminal epithelial cells, preantral and antral follicle cells in IR+EPH group. While caspase-3 activity increased in granulosa cells and stromal cells in IR group, caspase-3 expression was negative in preantral and antral follicle cells in the germinal epithelium and cortex in IR+EPH group. Conclusion: The effect of apoptosis, which occurs with the signaling that starts in the cell nucleus, caused the cessation of the stimulating effect at the nuclear level after EPH administration, and a decrease in the antioxidative effect in IR damage and inflammation in the apoptotic process.en_US
dc.identifier.citationToprak, V., Akalın, S. A., Öcal, E., Çavuş, Y. ve Deveci, E. (2023). Biochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissue. Acta Cirurgica Brasileira, 38, 1-8.
dc.identifier.doi10.1590/acb381523
dc.identifier.issn0102-8650
dc.identifier.pmid37132757
dc.identifier.scopus2-s2.0-85157972273
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/acb381523
dc.identifier.urihttps://hdl.handle.net/11468/23657
dc.identifier.volume38en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectApoptosisen_US
dc.subjectCaspase 3en_US
dc.subjectInterleukin-6en_US
dc.titleBiochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissueen_US
dc.titleBiochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissue
dc.typeArticleen_US

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