Chemical composition and pharmacological evaluation and of Ttddalia asiatica (Rutaceae) extracts and essential oil by in vitro and in silico approaches

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dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorLobine, Devina
dc.contributor.authorPairyanen, Bryan
dc.contributor.authorZengin, Gökhan
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorOuelbani, Rayene
dc.contributor.authorBensari, Souheir
dc.contributor.authorAk, Güneş
dc.contributor.authorAbdallah, Hassan H.
dc.contributor.authorImran, Muhammad
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2022-06-28T12:25:58Z
dc.date.available2022-06-28T12:25:58Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.descriptionWOS:000630326300001
dc.descriptionPMID: 33738900
dc.description.abstractToddalia asiatica (L.) Lam. is extensively used in traditional medicinal systems by various cultures. Despite its frequent use in traditional medicine, there is still a paucity of scientific information on T. asiatica growing on the tropical island of Mauritius. Therefore, the present study was designed to appraise the pharmacological and phytochemical profile of extracts (methanol, ethyl acetate and water) and essential oil obtained from aerial parts of T. asiatica. Biological investigation involved the evaluation of in vitro antioxidant and enzyme inhibitory potentials. The chemical profile of the EO was determined using gas chromatography coupled to mass spectrometry (GC/MS) analysis, while for the extracts, the total phenolic (TPC) and flavonoid content were quantified as well as their individual phenolic compounds by LC/MS/MS. Quinic acid, fumaric acid, chlorogenic acid, quercitrin and isoquercitrin were the main compounds in the extracts. Highest total phenolic (82.5 +/- 0.94 mg gallic acid equivalent (GAE/g)) and flavonoid (43.8 +/- 0.31 mg rutin equivalent (RE/g)) content were observed for the methanol extract. The GC/MS analysis has shown the presence of 26 compounds with linalool (30.9 %), linalyl acetate (20.9 %) and beta-phellandrene (7.9 %) being most abundant components in the EO. The extracts and EO showed notable antioxidant properties, with the methanol extract proved to be superior source of antioxidant compounds. Noteworthy anti-acetylcholinesterase (AChE) and anti-butyrylcholinesterase (BChE) effects were recorded for the tested samples, while only the methanol and ethyl acetate extracts were active against tyrosinase. With respect to antidiabetic effects, the extracts and EO were potent inhibitors of alpha-glucosidase, while modest activity was recorded against alpha-amylase. Docking results showed that linalyl acetate has the highest affinity to interact with the active site of BChE with docking score of -6.25 kcal/mol. The findings amassed herein act as a stimulus for further investigations of this plant as a potential source of bioactive compounds which can be exploited as phyto-therapeutics.en_US
dc.identifier.citationLobine, D., Pairyanen, B., Zengin, G., Yılmaz, M.A., Ouelbani, R., Bensari, S. ve diğerleri. (2021). Chemical composition and pharmacological evaluation and of Ttddalia asiatica (Rutaceae) extracts and essential oil by in vitro and in silico approaches. Chemistry & Biodiversity, 18(4), 1-12.en_US
dc.identifier.doi10.1002/cbdv.202000999
dc.identifier.endpage12en_US
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue4en_US
dc.identifier.pmid33738900
dc.identifier.scopus2-s2.0-85103039560
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.202000999
dc.identifier.urihttps://hdl.handle.net/11468/10075
dc.identifier.volume18en_US
dc.identifier.wosWOS:000630326300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag GMBHen_US
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEssential oilen_US
dc.subjectAntioxidant activityen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectMolecular dockingen_US
dc.subjectPhytomedicineen_US
dc.titleChemical composition and pharmacological evaluation and of Ttddalia asiatica (Rutaceae) extracts and essential oil by in vitro and in silico approachesen_US
dc.titleChemical composition and pharmacological evaluation and of Ttddalia asiatica (Rutaceae) extracts and essential oil by in vitro and in silico approaches
dc.typeArticleen_US

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