Assessment of antimicrobial and antioxidant activities of nepeta trachonitica: Analysis of its phenolic compounds using HPLC-MS/MS

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dc.authorid0000-0002-1026-972Xen_US
dc.authorid0000-0001-5993-1668en_US
dc.authorid0000-0001-7289-4507en_US
dc.contributor.authorKöksal, Ekrem
dc.contributor.authorTohma, Hatice
dc.contributor.authorKılıç, Ömer
dc.contributor.authorAlan, Yusuf
dc.contributor.authorAras, Abdülmelik
dc.contributor.authorGülçin, İlhami
dc.contributor.authorBursal, Ercan
dc.date.accessioned2024-03-20T11:52:27Z
dc.date.available2024-03-20T11:52:27Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesien_US
dc.description.abstractContinuing our work on the sources of natural bioactive compounds, we evaluated the antimicrobial and antioxidant activities of Nepeta trachonitica as well as its major phenolic content using the high-performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) technique. For antioxidant activity, ferric reducing antioxidant power (FRAP) and cupric ion reducing antioxidant capacity (CUPRAC) methods were performed to measure the reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was employed to evaluate the radical scavenging activity of the sample. For antimicrobial activity, three Gram-positive and four Gram-negative microbial species as well as three fungi species were tested. N. trachonitica appeared to have reasonable antioxidant activity and decent antimicrobial activity as indicated by the inhibition of the organisms’ growth. The most susceptible species were Bacillus subtilis ATCC 6633 and Escherichia coli ATCC 11229 among the organisms tested. Ethanol extract of the plant has the highest effect on Saccharomyces cerevisiae but no effect on Yarrowia lipolytica. The HPLC-MS/MS analysis showed that at least 11 major phenolic compounds of N. trachonitica exist, the major ones being rosmarinic acid, chlorogenic acid and quinic acid. The obtained results suggest that N. trachonitica could be a promising source for food and nutraceutical industries because of its antimicrobial and antioxidant properties and phenolic compounds.en_US
dc.identifier.citationKöksal, E., Tohma, H., Kılıç, Ö., Alan, Y., Aras, A., Gülçin, İ. ve diğerleri. (2017). Assessment of antimicrobial and antioxidant activities of nepeta trachonitica: Analysis of its phenolic compounds using HPLC-MS/MS. Scientia Pharmaceutica, 85(2), 1-14.en_US
dc.identifier.doi10.3390/scipharm85020024
dc.identifier.endpage14en_US
dc.identifier.issn0036-8709
dc.identifier.issue2en_US
dc.identifier.pmid28505129
dc.identifier.scopus2-s2.0-85020392250
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/2218-0532/85/2/24
dc.identifier.urihttps://hdl.handle.net/11468/13661
dc.identifier.volume85en_US
dc.identifier.wosWOS:000407342100009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAras, Abdülmelik
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofScientia Pharmaceutica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectHPLC-MS/MSen_US
dc.subjectNepeta trachoniticaen_US
dc.subjectPhenolic compoundsen_US
dc.titleAssessment of antimicrobial and antioxidant activities of nepeta trachonitica: Analysis of its phenolic compounds using HPLC-MS/MSen_US
dc.titleAssessment of antimicrobial and antioxidant activities of nepeta trachonitica: Analysis of its phenolic compounds using HPLC-MS/MS
dc.typeArticleen_US

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