A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)

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dc.authorid0000-0002-1412-1933en_US
dc.authorid0000-0002-3315-3893en_US
dc.authorid0000-0001-6029-1995en_US
dc.contributor.authorYıldırım, Halil Cumhur
dc.contributor.authorKupik, Gülnihan Eren
dc.contributor.authorMustafayev, Teuta Zoto
dc.contributor.authorBerber, Tanju
dc.contributor.authorYavuz, Berrin
dc.contributor.authorÇetinayak, Oğuz
dc.contributor.authorTeke, Fatma
dc.date.accessioned2023-10-17T11:08:23Z
dc.date.available2023-10-17T11:08:23Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: We aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. Methods: In a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. Results: Median age was 48 (9–83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6–78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age ≥50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). Conclusions: Patients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.en_US
dc.description.sponsorshipUniversity Grants Commission, India: 8- 4(57)/2015(MRP/NRCBen_US
dc.identifier.citationYıldırım, H. C., Kupik, G. E., Mustafayev, T. Z., Berber, T., Yavuz, B., Çetinayak, O. ve diğerleri. (2023). A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001). Head and Neck, 45(5), 1194-1205.en_US
dc.identifier.doi10.1002/hed.27333
dc.identifier.endpage1205en_US
dc.identifier.issn1043-3074
dc.identifier.issue5en_US
dc.identifier.pmid36854873
dc.identifier.scopus2-s2.0-85149269238
dc.identifier.scopusqualityQ1
dc.identifier.startpage1194en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/hed.27333
dc.identifier.urihttps://hdl.handle.net/11468/12825
dc.identifier.volume45en_US
dc.identifier.wosWOS:000940768500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTeke, Fatma
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofHead and Neck
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemoradiotherapyen_US
dc.subjectEBV-DNAen_US
dc.subjectIntensity-modulated radiotherapyen_US
dc.subjectNasopharyngeal carcinomaen_US
dc.subjectNonendemicen_US
dc.titleA multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)en_US
dc.titleA multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)
dc.typeArticleen_US

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