Detailed phytochemical evaluation of a locally endemic species (Campanula baskilensis) by LC-MS/MS and its in-depth antioxidant and enzyme inhibitory activities

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-8006-2054en_US
dc.authorid0000-0003-0788-4999en_US
dc.authorid0000-0001-6548-7823en_US
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorİzol, Ebubekir
dc.contributor.authorTarhan, Abbas
dc.contributor.authorBehçet, Lütfi̇
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2024-03-18T08:04:28Z
dc.date.available2024-03-18T08:04:28Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional-modern life, promotes the creation of new value-added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of Campanula baskilensis species, which belongs to the medicinally important genus Campanula L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different C. baskilensis extracts (ethanol, methanol, and water) by LC-MS/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC-MS/MS results revealed that, high amounts of quinic acid (53.6 mg/g aerial-MeOH extract), fumaric acid (6.3 mg/g aerial-H2O extract, 2.5 mg/g root-H2O extract), protocatechuic acid (11.4 mg/g aerial-H2O extract), vanillic acid (1.4 mg/g aerial-EtOH extract), quercetin-3-O-rutinoside (rutin) (2.3 mg/g aerial-EtOH extract), hesperetin 7-rutinoside (hesperidin) (2.0 mg/g aerial-EtOH extract), kaempferol-3-O-rutinoside (nicotiflorin) (5.5 mg/g aerial-EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on C. baskilensis extracts, aerial-H2O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.en_US
dc.identifier.citationYılmaz, M. A., Çakır, O., İzol, E., Tarhan, A., Behçet, L. ve Zengin, G. (2023). Detailed phytochemical evaluation of a locally endemic species (Campanula baskilensis) by LC-MS/MS and its in-depth antioxidant and enzyme inhibitory activities. Chemistry and Biodiversity, 20(12), 1-14.en_US
dc.identifier.doi10.1002/cbdv.202301182
dc.identifier.endpage14en_US
dc.identifier.issn1612-1872
dc.identifier.issue12en_US
dc.identifier.pmid37846496
dc.identifier.scopus2-s2.0-85177057804
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.202301182
dc.identifier.urihttps://hdl.handle.net/11468/13599
dc.identifier.volume20en_US
dc.identifier.wosWOS:001107544000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorÇakır, Oğuz
dc.institutionauthorTarhan, Abbas
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistry and Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectBioactivityen_US
dc.subjectCampanula baskilensisen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectLC-MS/MSen_US
dc.titleDetailed phytochemical evaluation of a locally endemic species (Campanula baskilensis) by LC-MS/MS and its in-depth antioxidant and enzyme inhibitory activitiesen_US
dc.titleDetailed phytochemical evaluation of a locally endemic species (Campanula baskilensis) by LC-MS/MS and its in-depth antioxidant and enzyme inhibitory activities
dc.typeArticleen_US

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