Functional Effects of Short-Term Treatment with Amiodarone on Thyroid Tissues of the Rabbit

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dc.contributor.authorAslan, Ibrahim
dc.contributor.authorAydin, Istem
dc.contributor.authorAydin, Ismet
dc.date.accessioned2024-04-24T16:02:37Z
dc.date.available2024-04-24T16:02:37Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe effect of short-term treatment with Amiodarone on thyroid gland tissue was studied in a group of 26 New Zealand albino rabbits. Ten rabbits were left untreated and served as controls; the remaining animals were treated with 10 mg/kg/day Amiodarone. The serum levels of serum triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) levels were measured at days 0 (baseline), 7, 30, and 45. The serum selenium levels were also measured, but only on days 0 and 45 of the experiment. At the end of the experiment the animals were sacrificed and the levels of selenium, T3, T4, and iodine were determined in thyroid tissue. After 30 days treatment the values of T3 were significantly lower than those of the untreated controls or the baseline levels (p < 0.001). The T4 level was significantly lower and the TSH value was significantly higher after 45 days of Amiodarone (p < 0.001). In thyroid tissue the T3, T4, and iodine levels were significantly higher in the treated group when compared to untreated controls (p < 0.05). These results show that Amiodarone induces changes in the hormone levels in both serum and thyroid tissues, as well as in the amount of iodine taken up by the thyroid gland in rabbits.en_US
dc.identifier.doi10.1007/s12011-009-8432-8
dc.identifier.endpage216en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid19547931
dc.identifier.scopus2-s2.0-77950354263
dc.identifier.scopusqualityQ1
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-009-8432-8
dc.identifier.urihttps://hdl.handle.net/11468/14858
dc.identifier.volume133en_US
dc.identifier.wosWOS:000274140600011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmiodaroneen_US
dc.subjectThyroiden_US
dc.subjectT4en_US
dc.subjectT3en_US
dc.subjectSeleniumen_US
dc.subjectIodineen_US
dc.titleFunctional Effects of Short-Term Treatment with Amiodarone on Thyroid Tissues of the Rabbiten_US
dc.titleFunctional Effects of Short-Term Treatment with Amiodarone on Thyroid Tissues of the Rabbit
dc.typeArticleen_US

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