Serum level of ADAMTS4 and ADAMTS8 in patients with psoriatic arthritis

Basit Öğe Kaydı
dc.authorid0000-0001-6160-5626en_US
dc.contributor.authorTaşkın, Irmak İçen
dc.contributor.authorKandemir, Sevgi İrtegün
dc.contributor.authorNas, Kemal
dc.contributor.authorDağlı, Abdullah Zübeyir
dc.date.accessioned2021-04-12T12:27:15Z
dc.date.available2021-04-12T12:27:15Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi BiyolojiAna Bilim Dalıen_US
dc.descriptionWOS:000618207400005
dc.description.abstractObjective: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a large family of proteoglycanase enzymes that show proteolytic activity. The expression levels of ADAMTS proteases in osteoarthritis and rheumatoid arthritis are upregulated. However, their expression levels in PsA patients have not been examined yet. The aim of this study was to determine the serum levels of ADAMTS4 and ADAMTS8 in PsA patients. Materials and Methods: This was a case-control study and enrolled 40 PsA patients and 40 individuals as controls. Serum levels of ADAMTS4 and ADAMTS8 were examined by the enzyme-linked immunosorbent assay (ELISA). The relationship between ADAMTS8 levels and demographic and clinical features of PsA patients were analyzed. Results: The results of this study showed that the ADAMTS8 level was significantly elevated in the serum of PsA patients (160.9 +/- 49.79 pg/mL) compared to the control groups (<15.6 pg/mL). An association (r=0.32, p<0.05) was detected between age and serum level of ADAMTS8. However, the level of the ADAMTS4 in many subjects was under the detectable range. Conclusion: Our results conclude that a relationship exists between ADAMTS8 and PsA, but further investigations are required to establish the function of ADAMTS8 proteases in PsA.en_US
dc.identifier.citationTaşkın, I.İ., Kandemir, S.İ., Nas, K. ve Dağlı, A.Z. (2021). Serum level of ADAMTS4 and ADAMTS8 in patients with psoriatic arthritis. Erciyes Medical Journal, 43(1), 20-25.en_US
dc.identifier.doi10.14744/etd.2020.65625
dc.identifier.endpage25en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue1en_US
dc.identifier.startpage20en_US
dc.identifier.trdizinid485629
dc.identifier.urihttps://jag.journalagent.com/erciyesmedj/pdfs/EMJ_43_1_20_25.pdf
dc.identifier.urihttps://hdl.handle.net/11468/6682
dc.identifier.volume43en_US
dc.identifier.wosWOS:000618207400005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherErciyes University School of Medicineen_US
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPsoriatic arthritisen_US
dc.subjectADAMTS4en_US
dc.subjectADAMTS8en_US
dc.subjectBiomarkersen_US
dc.titleSerum level of ADAMTS4 and ADAMTS8 in patients with psoriatic arthritisen_US
dc.titleSerum level of ADAMTS4 and ADAMTS8 in patients with psoriatic arthritis
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Serum Level of ADAMTS4 and ADAMTS8.pdf
Boyut:
219.09 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu