The relationship between complete hydatidiform mole and serum Vitamin D level: a prospective case-control study

OBJECTIVE: This study aimed to determine whether or not there was a relations-hip between complete hydatidiform mole (CHM) and serum Vitamin D level by comparing CHM patients with two control groups and to determi-ne whether or not Vitamin D deficiency is a risk factor for CHM. PATIENTS AND METHODS: This prospec-tive study included 30 patients diagnosed with CHM (case group), 30 patients in the first trimes-ter of a healthy pregnancy (control group), and 30 healthy non-pregnant subjects (control group). A record was made of serum 25-hydroxyvitamin D (25-OH D vitamin) levels, age, body mass index (BMI), gravida, parity, and the number of abortus. The serum 25-OH D vitamin levels were examined in each group and compared between groups. RESULTS: The 25-OH D vitamin level of all the patients in the study was determined as 11.16 +/- 8.64 ng/mL. No significant difference was determined between the groups in respect of 25 OH-D vitamin levels. When comparisons were made between the four subgroups according to the 25-OH-D level, no significant difference was determined between the CHM and control groups. When the patients were separated as obese and non-obese groups, no significant dif-ference was determined between the groups. CONCLUSIONS: Severe deficiency, deficien-cy, or insufficient levels of serum Vitamin D are not thought to be risk factors for CHM patients.