The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women

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dc.contributor.authorAtamer, Y
dc.contributor.authorErden, AC
dc.contributor.authorDemir, B
dc.contributor.authorKoçyigit, Y
dc.contributor.authorAtamer, A
dc.date.accessioned2024-04-24T17:11:29Z
dc.date.available2024-04-24T17:11:29Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground To clarify the role of leptin and androgens in the pathogenesis of preeclampsia, we wanted to assess role of maternal leptin in women with severe and mild preeclampsia and the effects of sex steroid hormones on leptin production. Methods. The groups consisted of 40 healthy pregnant women (HPW) as well as 55 pregnant women with severe preeclampsia (SPE) and 41 pregnant women with mild preeclampsia (MPE). No significant differences were observed between the three groups regarding age, gestational age and body mass index (BMI). Plasma leptin, total testosterone (T), estradiol (EA dehydroepiandrosterone sulfate (DHEAS) and androstenedione (A) levels were measured. Statistical analysis was achieved with one-way analysis of variance (ANOVA) followed by post hoc multiple comparisons with the Tukey honestly significant difference (HSD) test by using SPSS for Windows statistical computer program, and the Pearson's coefficient of correlation was calculated. Results. The plasma level of leptin was significantly increased in the SPE and MPE groups (p < 0.001), whereas the plasma level of T was significantly increased only in the SPE group (p < 0.001). However, there was no significant difference in plasma levels of DHEAS among the three groups (p < 0.05). The plasma level of A was significantly decreased in the MPE group (p < 0.05). There was no significant difference in the plasma level of E-2 in the MPE and SPE groups (p < 0.05). There was a significant positive correlation between the plasma levels of leptin and E-2 in the MPE group (r = 0.41, P < 0.001). Conclusion. We concluded that the elevated plasma levels of leptin and testosterone could contribute to the endothelial dysfunction involved in the pathogenesis of preeclampsia, and that estradiol might lead to an increase in the plasma levels of leptin.en_US
dc.identifier.doi10.1111/j.0001-6349.2004.00276.x
dc.identifier.endpage430en_US
dc.identifier.issn0001-6349
dc.identifier.issue5en_US
dc.identifier.pmid15059152
dc.identifier.scopus2-s2.0-2042512337
dc.identifier.scopusqualityQ1
dc.identifier.startpage425en_US
dc.identifier.urihttps://doi.org/10.1111/j.0001-6349.2004.00276.x
dc.identifier.urihttps://hdl.handle.net/11468/17551
dc.identifier.volume83en_US
dc.identifier.wosWOS:000221059400002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBlackwell Munksgaarden_US
dc.relation.ispartofActa Obstetricia Et Gynecologica Scandinavica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeptinen_US
dc.subjectPreeclampsiaen_US
dc.subjectPregnancyen_US
dc.subjectAndrogensen_US
dc.titleThe relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant womenen_US
dc.titleThe relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women
dc.typeArticleen_US

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