Investigation of carbapenemase and MCR-1 genes in carbapenem-resistant klebsiella pneumoniae isolates

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dc.contributor.authorArabacı, Çiğdem
dc.contributor.authorDal, Tuba Demirel
dc.contributor.authorBaşyi̇ği̇t, Tuğcan
dc.contributor.authorGenişel, Neslihan
dc.contributor.authorDurmaz, Rıza
dc.date.accessioned2021-09-14T10:40:51Z
dc.date.available2021-09-14T10:40:51Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.descriptionPMID:32058985
dc.description.abstractIntroduction: Carbapenem-resistant Klebsiella pneumoniae are a major problem. We aimed to investigate carbapenemase-encoding genes and transferable mcr-1 genes among 57 carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from hospitalized patients. Methodology: Antibiotic susceptibility tests were performed by Phoenix (BD). Results for ertapenem and colistin were confirmed by gradient diffusion and microdilution methods. Carbapenemase and mcr-1 genes were investigated by Polymerase Chain Reaction (PCR). Results: Thirty-two (56.14%) isolates were from intensive care units (ICU). Antibiotic resistance rates by Phoenix: 52.63% for amikacin; 73.69% trimethoprim sulfamethoxazole; 91.23% cefepime; 82.46% tigecycline; 59.65% colistin. Carbapenemases positivity: 82.45% (47) for blaOXA-48, 40.35% (23) blaOXA-55, 3.50% (2) blaOXA-51, 1.75% (1) blaOXA-23, 1.75% (1) blaOXA-24, 1.75% (1) blaIMP. blaOXA-58, blaKPC, blaNDM-1, and blaVIM were not detected. Twenty (35.08%) isolates had both blaOXA-48 and blaOXA-55. Three isolates were mcr-1 (+) and blaOXA-48 (+). One mcr-1 (+) isolates was blaOXA-51 (+). One colistin sensitive isolate determined by Phoenix, was found colistin resistant by microdilution. Conclusion: OXA-48 and OXA-55 co-harboring isolates and mcr-1 gene (+) isolates were spreading. Automated colistin susceptibility results should be confirmed by microdilution method. Resistance mechanisms in Enterobacteriaceae should be determined and the isolates should be monitored by molecular epidemiological methods. Effective infection control measures will contribute to reduce risk of antibiotic resistant bacterial infections and dissemination of antibiotic resistance.en_US
dc.identifier.citationArabacı, Ç., Dal, T. D., Başyi̇ği̇t, T., Genişel, N. ve Durmaz, R. (2019). Investigation of carbapenemase and MCR-1 genes in carbapenem-resistant klebsiella pneumoniae isolates. Journal of Infection in Developing Countries, 13(6), 504-509.en_US
dc.identifier.doi10.3855/jidc.11048
dc.identifier.endpage509en_US
dc.identifier.issn2036-6590
dc.identifier.issue6en_US
dc.identifier.pmid32058985
dc.identifier.scopus2-s2.0-85069870147
dc.identifier.scopusqualityQ2
dc.identifier.startpage504en_US
dc.identifier.urihttps://jidc.org/index.php/journal/article/view/11048
dc.identifier.urihttps://hdl.handle.net/11468/7549
dc.identifier.volume13en_US
dc.identifier.wosWOS:000475711700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGenişel, Neslihan
dc.language.isoenen_US
dc.publisherJournal of Infection in Developing Countriesen_US
dc.relation.ispartofJournal of Infection in Developing Countries
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbapenemen_US
dc.subjectColistinen_US
dc.subjectResistanceen_US
dc.titleInvestigation of carbapenemase and MCR-1 genes in carbapenem-resistant klebsiella pneumoniae isolatesen_US
dc.titleInvestigation of carbapenemase and MCR-1 genes in carbapenem-resistant klebsiella pneumoniae isolates
dc.typeArticleen_US

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