Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease

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dc.contributor.authorOnat, Altan
dc.contributor.authorCan, Gunay
dc.contributor.authorOrnek, Ender
dc.contributor.authorAltay, Servet
dc.contributor.authorYuksel, Murat
dc.contributor.authorAdemoglu, Evin
dc.date.accessioned2024-04-24T16:02:00Z
dc.date.available2024-04-24T16:02:00Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe explored the association of serum uric acid (UA) concentrations with pro-inflammatory state and high-density lipoprotein (HDL) dysfunction. UA tertiles in tracked 1,508 nondiabetic participants were analyzed cross-sectionally for associations with inflammation biomarkers and protective proteins over a mean follow-up of 4.9 years for incident coronary heart disease (CHD) using Cox proportional hazards regression. In the absence of metabolic syndrome (MetS), UA tertiles significantly distinguished, in each sex, increasing categories of three MetS components (inflammation/oxidation markers, apolipoprotein (apo)B) and (inversely) current smoking (but not protective proteins such as HDL, apoA-I, and adiponectin). Distinctions attenuated in the presence of MetS. Linear regression model revealed fasting triglycerides (1.86 mg/dl variance), male sex, and gamma-glutamyl transferase and age as covariates of UA levels in women. In Cox analysis, incident CHD (n = 137) was predicted by mid and upper UA tertile in men alone at significant hazard ratios of 2.7, additively to conventional risk factors. Elevated serum UA levels, linked to triglycerides, mark in nondiabetic people pro-inflammatory state, and, notably, HDL dysfunction. CHD risk is independently predicted by elevated UA levels in nondiabetic men and is modulated by MetS and gender.en_US
dc.description.sponsorshipTurkish Society of Cardiologyen_US
dc.description.sponsorshipThe Turkish Society of Cardiology is gratefully acknowledged for its support to the Turkish Adult Risk Factor study. We appreciate the dedicated work of past members in the survey teams.en_US
dc.identifier.doi10.1007/s10067-013-2339-7
dc.identifier.endpage1775en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue12en_US
dc.identifier.pmid23934383
dc.identifier.scopus2-s2.0-84890428013
dc.identifier.scopusqualityQ1
dc.identifier.startpage1767en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-013-2339-7
dc.identifier.urihttps://hdl.handle.net/11468/14558
dc.identifier.volume32en_US
dc.identifier.wosWOS:000327402500010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Heart Disease Risken_US
dc.subjectHdl Dysfunctionen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectPro-Inflammatory Stateen_US
dc.subjectSerum Uric Aciden_US
dc.titleElevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary diseaseen_US
dc.titleElevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease
dc.typeArticleen_US

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