Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride

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dc.contributor.authorGok, Ertugrul
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:15:11Z
dc.date.available2024-04-24T17:15:11Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: This study aims to evaluate the changes in brain tissue and blood-brain barrier due to oxidative stress during cadmium (Cd) poisoning by biochemical, histopathological, and immunohistochemical methods.Methods: 170-190 g weighing eight-week-old female Wistar albino rats were divided into two groups (control and experimental), with 7 animals in each group. Experimental group rats were given 2 mg/kg/day powdered cadmium chloride dissolved in water intraperitoneally every day for two weeks. Biochemical, histopathological and immunohistochemical examination was performed.Results: It was seen that brain malondialdehyde (MDA) levels increased significantly, and glutathione (GSH) and catalase (CAT) activity levels decreased. In addition to degeneration in some pyramidal cells and glial cells, deformity, and picnosis in the nucleus, dilation of the meninges and cortex vessels, and inflammation around the blood vessels were observed. An increase was found in ionized calcium binding adaptor molecule 1 (IBA-1) expression in microglia cells and degenerative endothelial cells, and increased glial fibrillary acidic protein (GFAP) expression was observed in astrocytes and degenerate neurons.Conclusions: It has been shown that cadmium toxicity may cause microgliosis and astrogliogenesis by inducing cytokine production due to cell degeneration, vascularity, and inflammation in the brain cortex and by affecting microglia, astrocytes cells.en_US
dc.identifier.doi10.12871/000398292022122
dc.identifier.endpage29en_US
dc.identifier.issn0003-9829
dc.identifier.issue1-2en_US
dc.identifier.pmid35913387
dc.identifier.scopus2-s2.0-85135500443
dc.identifier.scopusqualityQ4
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.12871/000398292022122
dc.identifier.urihttps://hdl.handle.net/11468/18366
dc.identifier.volume160en_US
dc.identifier.wosWOS:000948381000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPisa Univ Pressen_US
dc.relation.ispartofArchives Italiennes De Biologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCadmiumen_US
dc.subjectBrain Tissueen_US
dc.subjectBlood-Brain Barrieren_US
dc.subjectOxidative Stressen_US
dc.subjectToxicityen_US
dc.titleHistopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chlorideen_US
dc.titleHistopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride
dc.typeArticleen_US

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