18F-FDG PET/CT parameters for prediction of response to neoadjuvant therapy and prognosis in rectal cancer

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dc.authorid0000-0002-7931-2941en_US
dc.authorid0000-0001-7858-8180en_US
dc.authorid0000-0003-0882-0524en_US
dc.authorid0000-0001-7336-871Xen_US
dc.authorid0000-0002-7451-2786en_US
dc.contributor.authorEbinç, Senar
dc.contributor.authorGüzel, Yunus
dc.contributor.authorOruç, Zeynep
dc.contributor.authorKömek, Halil
dc.contributor.authorKalkan, Ziya
dc.contributor.authorCan, Canan
dc.contributor.authorTaşdemir, Bekir
dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2023-08-04T07:51:59Z
dc.date.available2023-08-04T07:51:59Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractObjective This study aims to investigate the role of F-18 fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) parameters in the prediction of treatment response and the prognosis in locally advanced rectal cancer. Methods We investigated the relationship of 18F-FDG PET/CT parameters [rectal metabolic tumor volume (MTV), rectal total lesion glycolysis (TLG), rectal standard uptake value (SUV) max, rectal highest peak SUV, lymph node MTV, lymph node TLG, lymph node highest peak SUV] with the pathological response and disease-free survival (DFS) in 60 patients who received neoadjuvant therapy for a diagnosis of locally advanced rectal cancer. Patients with a total score of 0 were assigned to the low-risk group, patients with a score of 1 were assigned to the intermediate-risk group and patients with a score of 2 were assigned to the high-risk group. Results The multivariate analysis revealed that, from baseline PET CT parameters, lymph node highest peak SUV strongly predicted the pathological response at a cutoff value of 2.23. DFS was predicted by the lymph node highest peak SUV at a cutoff value of 3.13 and by the MTV value at a cutoff value of 27 cm3. The risk scoring performed with regard to rectal MTV and lymph node highest peak SUV values determined a median DFS of 19 months in patients with a risk score of 2, whereas the median DFS was not reached in patients with risk scores of 0 and 1 (P < 0.001). Conclusion This study determined that rectal MTV and lymph node highest peak SUV predicted the response to neoadjuvant therapy and DFS.en_US
dc.identifier.citationEbinç, S., Güzel, Y., Oruç, Z., Kömek, H., Kalkan, Z., Can, C. ve diğerleri. (2023). 18F-FDG PET/CT parameters for prediction of response to neoadjuvant therapy and prognosis in rectal cancer. Nuclear Medicine Communications, 44(1), 81-90.en_US
dc.identifier.doi10.1097/MNM.0000000000001638
dc.identifier.endpage90en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue1en_US
dc.identifier.pmid36437550
dc.identifier.scopus2-s2.0-85144269758
dc.identifier.scopusqualityQ3
dc.identifier.startpage81en_US
dc.identifier.urihttps://journals.lww.com/nuclearmedicinecomm/Fulltext/2023/01000/18F_FDG_PET_CT_parameters_for_prediction_of.11.aspx
dc.identifier.urihttps://hdl.handle.net/11468/12431
dc.identifier.volume44en_US
dc.identifier.wosWOS:000898084600011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOruç, Zeynep
dc.institutionauthorKalkan, Ziya
dc.institutionauthorTaşdemir, Bekir
dc.institutionauthorUrakçı, Zuhat
dc.institutionauthorKaplan, Muhammet Ali
dc.institutionauthorKüçüköner, Mehmet
dc.institutionauthorIşıkdoğan, Abdurrahman
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.ispartofNuclear Medicine Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectMetabolic tumor volumeen_US
dc.subjectRectumen_US
dc.subjectStandard uptake valueen_US
dc.title18F-FDG PET/CT parameters for prediction of response to neoadjuvant therapy and prognosis in rectal canceren_US
dc.title18F-FDG PET/CT parameters for prediction of response to neoadjuvant therapy and prognosis in rectal cancer
dc.typeArticleen_US

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