Effects of hyperbaric oxygen on crystalline lens and retina in nicotine-exposed rats

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dc.contributor.authorAri, Seyhmus
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorCingu, Abdullah Kursat
dc.contributor.authorAtay, Ahmet Engin
dc.contributor.authorSahin, Alparslan
dc.contributor.authorCinar, Yasin
dc.contributor.authorCaca, Ihsan
dc.date.accessioned2024-04-24T17:20:34Z
dc.date.available2024-04-24T17:20:34Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To determine histopathological changes on crystalline lens and retina of rats after subcutaneous injection of nicotine and to examine the effects of hyperbaric oxygen (HBO) on these changes related to nicotine exposure. Methods: Twenty-eight female Sprague-Dawley rats were enrolled in the study and the rats were divided into four equal sized groups randomly (Group N: the rats exposed only to nicotine, group HB: the rats received only HBO, group N+HB: the rats that underwent to nicotine injection and subsequently received HBO, group C: the control group that neither exposed to nicotine nor received HBO). The rats were sacrified by decapitation method and all were enucleated immediately after scarification. Tissue samples from crystalline lens, lens capsule, and the retina from the right eyes of the rats were examined by light microscopy. Results: While the histological appearances of the retina and the lens was similar in group HB, group N+HB, and the control group; group N showed some pathological changes like decrement in the retinal ganglion cell density, atrophy of the retinal nerve fiber layer, congestion of the vessels in the optic nerve head, thinning of the internal plexiform layer, thinning of the lens capsule, and transformation of the anterior subcapsular epithelium into squamous epithelia. Discussion: Subcutaneous injection of nicotine was found to be related with some pathological changes in the retina and lens of the Sprague-Dawley rats. However HBO caused no significant negative effect. Furthermore, the histopathological changes related to nicotine exposure in the lens and retina of the rats recovered by the application of HBO.en_US
dc.identifier.doi10.3109/15569527.2012.686078
dc.identifier.endpage12en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue1en_US
dc.identifier.pmid22667328
dc.identifier.scopus2-s2.0-84868540996
dc.identifier.scopusqualityQ3
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2012.686078
dc.identifier.urihttps://hdl.handle.net/11468/19138
dc.identifier.volume32en_US
dc.identifier.wosWOS:000310618400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNicotineen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectCrystalline Lensen_US
dc.subjectRetinaen_US
dc.titleEffects of hyperbaric oxygen on crystalline lens and retina in nicotine-exposed ratsen_US
dc.titleEffects of hyperbaric oxygen on crystalline lens and retina in nicotine-exposed rats
dc.typeArticleen_US

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