The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study

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dc.contributor.authorYalinkaya, A
dc.contributor.authorErdemoglu, M
dc.contributor.authorAkdeniz, N
dc.contributor.authorKale, A
dc.contributor.authorKale, E
dc.date.accessioned2024-04-24T17:24:59Z
dc.date.available2024-04-24T17:24:59Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Preeclampsia and its association with thrombophilia remain controversial, dueto inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between thrombophilia and preeclamptic patients in our region. METHODS: In a prospective case-control study, we compared 100 consecutive women with preeclampsia and eclampsia (group 1) with 100 normal pregnant women (group 2). All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III. RESULTS: A thrombophilic mutation was found in 42 (42%) and 28 (28%) women in group 1 and group 2, respectively (P=0.27, OR 1.5, 95% CI 1.0-2.2). The incidence of Factor V Leiden mutation (heterozygous), prothrombin mutation (heterozygous), prothrombin mutation (homozygous), MTHFR mutation (homozygous) was not statistically significant in group 1 compared with group 2 (P > 0.05). Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 (P > 0.05). CONCLUSION: There was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women in our region. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia.en_US
dc.identifier.doi10.5144/0256-4947.2006.105
dc.identifier.endpage109en_US
dc.identifier.issn0256-4947
dc.identifier.issue2en_US
dc.identifier.pmid16761446
dc.identifier.scopus2-s2.0-33646818342
dc.identifier.scopusqualityQ2
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2006.105
dc.identifier.urihttps://hdl.handle.net/11468/19899
dc.identifier.volume26en_US
dc.identifier.wosWOS:000237932300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherK Faisal Spec Hosp Res Centreen_US
dc.relation.ispartofAnnals of Saudi Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe relationship between thrombophilic mutations and preeclampsia: a prospective case-control studyen_US
dc.titleThe relationship between thrombophilic mutations and preeclampsia: a prospective case-control study
dc.typeArticleen_US

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