The effect of high-fat diet on the development of obesity and serum leptin level in rats

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dc.contributor.authorBahçeci, Mithat
dc.contributor.authorTuzcu, Alpaslan Kemal
dc.contributor.authorAkkuş, Murat
dc.contributor.authorYaldız, Mehmet Sadık
dc.contributor.authorÖzbay, A.
dc.date.accessioned2024-04-24T17:56:04Z
dc.date.available2024-04-24T17:56:04Z
dc.date.issued1999
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractTen male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5±5, at sixth month 268±19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177±6.4, at sixth month 220±10 g). At the sixth month, mean body fat percentages were 36.3±6.7% and 24.2±5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p<0.01 and p<0.05 respectively). The livers of all rats were histopathologically normal. Conclusion: high-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia.en_US
dc.identifier.citationBahçeci, M., Tuzcu, A. K., Akkuş, M., Yaldız, M. S. ve Özbay, A. (1999). The effect of high-fat diet on the development of obesity and serum leptin level in rats. Eating and Weight Disorders, 4(3), 128-132.
dc.identifier.doi10.1007/BF03339728
dc.identifier.endpage132en_US
dc.identifier.issn1124-4909
dc.identifier.issue3en_US
dc.identifier.pmid11234241
dc.identifier.scopus2-s2.0-0033188475
dc.identifier.scopusqualityQ1
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.1007/BF03339728
dc.identifier.urihttps://hdl.handle.net/11468/23248
dc.identifier.urihttps://link.springer.com/article/10.1007/BF03339728
dc.identifier.volume4en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer International Publishingen_US
dc.relation.ispartofEating and Weight Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-fat dieten_US
dc.subjectLeptinen_US
dc.subjectLipid profileen_US
dc.subjectObesityen_US
dc.titleThe effect of high-fat diet on the development of obesity and serum leptin level in ratsen_US
dc.titleThe effect of high-fat diet on the development of obesity and serum leptin level in rats
dc.typeArticleen_US

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