The effect of high-fat diet on the development of obesity and serum leptin level in rats
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Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer International Publishing
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5±5, at sixth month 268±19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177±6.4, at sixth month 220±10 g). At the sixth month, mean body fat percentages were 36.3±6.7% and 24.2±5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p<0.01 and p<0.05 respectively). The livers of all rats were histopathologically normal. Conclusion: high-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia.
Açıklama
Anahtar Kelimeler
High-fat diet, Leptin, Lipid profile, Obesity
Kaynak
Eating and Weight Disorders
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
4
Sayı
3
Künye
Bahçeci, M., Tuzcu, A. K., Akkuş, M., Yaldız, M. S. ve Özbay, A. (1999). The effect of high-fat diet on the development of obesity and serum leptin level in rats. Eating and Weight Disorders, 4(3), 128-132.
