The effects of Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice

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dc.contributor.authorGeyik, Mehmet Faruk
dc.contributor.authorAldemir, Mustafa
dc.contributor.authorHosoglu, Salih
dc.contributor.authorAyaz, Celal
dc.contributor.authorSatilmis, Selda
dc.contributor.authorBuyukbayram, Huseyin
dc.contributor.authorKokoglu, Omer Faruk
dc.date.accessioned2024-04-24T17:15:20Z
dc.date.available2024-04-24T17:15:20Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractINTRODUCTION The aim of this study was to investigate the effect of Saccharomyces boulardii treatment on preventing bacterial translocation in an obstructive jaundice animal model. MATERIALS AND METHODS Sixty adult rats were divided into five groups: group 1 - the sham-operated group; group 2 - the common bile duct ligation group; group 3 - the S. boulardii group; group 4 - the ampicillin-sulbaktam group; and group 5 the S. boulardii plus ampicillin-sulbaktam group. The saline, antibiotics and S. boulardii were given, respectively, for a 7-day period as a single dose per day via temporary orogastric intubation. Seven days following the obstructive jaundice, the animal had laparatomy under sterile conditions. Segments of ileum were removed for histopathological examination. Blood, liver, spleen and mesenteric lymph nodes were taken for microbiological culture. RESULTS Bacterial translocation rates were 0% in the sham-operated group, 83% in group 2, 42% in group 3, 42% in group 4 and 33% in group 5. Bacterial translocation significantly increased in group 2 compared to groups 3, 4 and 5 (P = 0.001). The bacterial counts (CFU/g) of group 2 were significantly higher than those of groups 3, 4 and 5 (P = 0.001). Histopathological examination of ileum specimens revealed a significant decrease in the heights of villi in groups 2-5 compared to the sham-operated group (P = 0.001). The mean villus height in groups 3 and 5 was significantly higher than that of group 4 (P = 0.001). CONCLUSIONS S. boulardii was found to be effective in the successful control of translocation and improvement of intestinal barrier function.en_US
dc.identifier.doi10.1308/003588406X94986
dc.identifier.endpage180en_US
dc.identifier.issn0035-8843
dc.identifier.issue2en_US
dc.identifier.pmid16551414
dc.identifier.scopus2-s2.0-33644958017
dc.identifier.scopusqualityQ2
dc.identifier.startpage176en_US
dc.identifier.urihttps://doi.org/10.1308/003588406X94986
dc.identifier.urihttps://hdl.handle.net/11468/18422
dc.identifier.volume88en_US
dc.identifier.wosWOS:000247866500027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherRoyal Coll Surgeons Englanden_US
dc.relation.ispartofAnnals of The Royal College of Surgeons of England
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSaccharomyces Boulardiien_US
dc.subjectBileen_US
dc.subjectObstructiveen_US
dc.subjectJaundiceen_US
dc.subjectTranslocationen_US
dc.titleThe effects of Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundiceen_US
dc.titleThe effects of Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice
dc.typeArticleen_US

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