The prognostic importance of serum IL-1?, IL-6, IL-8 and TNF-? levels compared to trauma scoring systems for early mortality in children with blunt trauma

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dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorYagmur, Yusuf
dc.contributor.authorOzturk, Hulya
dc.date.accessioned2024-04-24T16:00:12Z
dc.date.available2024-04-24T16:00:12Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of the present study was to determine whether a correlation exits between the main trauma scoring systems and the activation of inflammatory cells and mediators such as interleukin-(IL-) 1 beta, IL-6, IL-8 and tumor necrosis factor alpha (TNF-alpha) after trauma, and moreover to assess if any of these can be used to predict the outcome in patients under care at a trauma center. Forty-seven children (37 boys, 10 girls) presenting with blunt trauma, were evaluated by an analysis of the relationship between overall mortality and potential risk factors. Admission data, including serum IL-1 beta, IL-6, IL-8, TNF-alpha, pediatric trauma score (PTS), and injury severity score (ISS), were collected and analyzed. In descriptive statistics for independent variables, some prognostic factors such as IL-8 (P = 0.04), and ISS (P = 0.004) were significant in their relationship to mortality. In the univariate statistical analysis some other risk factors such as IL-8 (P = 0.004), > 20 TNF-alpha (P = 0.04), and ISS (P = 0.007) were significant in their relationship to mortality. The relative risk of developing mortality was higher than two for each of the following risk factors: > 10 ages, > 25 IL-6, 10-20 TNF-alpha, > 20 TNF-alpha, PTS <= 8, and ISS > 15. There was a positive correlation between IL-8 (r = 0.31, P = 0.33), ISS (r = 0.31, P = 0.0001), and mortality. There was also a correlation with ISS and IL-8 (r = 0.32, P = 0.02). ISS, and the serum IL-8 level are the most important determinants of clinical outcome in critically injured patients. A correlation exits between IL-8 and mortality and between ISS and IL-8.en_US
dc.identifier.doi10.1007/s00383-007-2083-7
dc.identifier.endpage239en_US
dc.identifier.issn0179-0358
dc.identifier.issue2en_US
dc.identifier.pmid18060414
dc.identifier.scopus2-s2.0-38549165767
dc.identifier.scopusqualityQ2
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-007-2083-7
dc.identifier.urihttps://hdl.handle.net/11468/14405
dc.identifier.volume24en_US
dc.identifier.wosWOS:000252676000017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTraumaen_US
dc.subjectTrauma Scoring Systemen_US
dc.subjectCytokinesen_US
dc.subjectChilden_US
dc.titleThe prognostic importance of serum IL-1?, IL-6, IL-8 and TNF-? levels compared to trauma scoring systems for early mortality in children with blunt traumaen_US
dc.titleThe prognostic importance of serum IL-1?, IL-6, IL-8 and TNF-? levels compared to trauma scoring systems for early mortality in children with blunt trauma
dc.typeArticleen_US

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