Influence of the platelet-activating factor receptor antagonist BB-882 on intra-abdominal adhesion formation in rats

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dc.contributor.authorOtcu, S
dc.contributor.authorOzturk, H
dc.contributor.authorAldemir, M
dc.contributor.authorKilinc, N
dc.contributor.authorDokucu, AI
dc.date.accessioned2024-04-24T17:14:26Z
dc.date.available2024-04-24T17:14:26Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractPostoperative intra-abdominal adhesion formation is a major clinical problem. We aimed to examine the preventive effect of treatment with the platelet-activating factor (PAF) antagonist (lexipafant, BB-882) on experimentally induced intra-abdominal adhesion formation in rats. Twenty male Sprague-Dawley rats weighing 250 and 290 g were studied. Generation of adhesions in rats by brushing a 1-cm(2) area of the cecum and the peritoneum on the right side of the abdominal wall was followed by intra-abdominal administration of saline and 5 mg/kg in a volume of 0.2 ml PAF receptor antagonist BB-882. After 45 days, formation of adhesions was graded and histological evaluation was processed. The severity of adhesions was significantly less in the BB-882 group than in the control group (p < 0.001, p < 0.05). The average adhesion scores in the control and BB-882 groups were 3.2 +/- 0.6 and 0.6 +/- 0.6, respectively, and the difference between both groups was found to be significant (p < 0.0001). The number of polymorphonuclear leukocytes and fibrotic areas was significantly decreased in the BB-882 group when compared to the control group (p < 0.001, p < 0.002). In conclusion, this study confirms the efficacy of BB-882 in the prevention of postoperative intra-abdominal adhesions in a rat model. Copyright (C) 2003 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000067034
dc.identifier.endpage45en_US
dc.identifier.issn0014-312X
dc.identifier.issn1421-9921
dc.identifier.issue1en_US
dc.identifier.pmid12566786
dc.identifier.scopus2-s2.0-0037234981
dc.identifier.scopusqualityQ2
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1159/000067034
dc.identifier.urihttps://hdl.handle.net/11468/17939
dc.identifier.volume35en_US
dc.identifier.wosWOS:000180911400007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofEuropean Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBb-882en_US
dc.subjectLexipafanten_US
dc.subjectPostoperative Intraperitoneal Adhesionsen_US
dc.titleInfluence of the platelet-activating factor receptor antagonist BB-882 on intra-abdominal adhesion formation in ratsen_US
dc.titleInfluence of the platelet-activating factor receptor antagonist BB-882 on intra-abdominal adhesion formation in rats
dc.typeArticleen_US

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