Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones

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dc.contributor.authorAlkış, Mehmet Eşref
dc.contributor.authorAkdağ, Memet Zülküf
dc.contributor.authorDaşdağ, Süleyman
dc.contributor.authorYeǧin, Korkut
dc.contributor.authorAkpolat, Veysi
dc.date.accessioned2021-09-29T05:54:56Z
dc.date.available2021-09-29T05:54:56Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractThe testes are a sensitive organ to electromagnetic pollution and people are concerned about the harmful effects of the radiofrequency radiation (RFR) emitted from cellular phones. Therefore, the purpose of this study was to investigate the effects of long-term exposure to different RFR frequencies on single-strand DNA breaks and oxidative changes in rat testicular tissue. Twenty-eight male Sprague–Dawley rats were divided randomly into four groups. Three groups were exposed to radiation emitted from 900, 1800 and 2100 MHz RF generators, 2 h/day for 6 months. The sham-control group was kept under the same experimental conditions but the RFR generator was turned off. Immediately after the last exposure, testes were removed and DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were analyzed. The results of this study indicated that RFR increased TOS, OSI, MDA and 8-OHdG (p < 0.05). TAS levels in the exposed group were lower than in the sham group (p < 0.05). In terms of DNA damage, the tail intensities in the comet assay were higher in the exposure groups (p < 0.05). This study demonstrated that long-term exposure to RFR emitted by cellular phones may cause oxidative stress and oxidative DNA damage in rat testicular tissue and may generate DNA single-strand breaks at high frequencies (1800 and 2100 MHz). Our results showed that some RFR emitted from cellular phones has potential to lead to cell damage in the testes.en_US
dc.identifier.citationAlkış, M. E., Akdağ, M. Z., Daşdağ, S., Yeǧin, K. ve Akpolat, V. (2019). Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones. Biotechnology and Biotechnological Equipment, 33(1), 1733-1740.en_US
dc.identifier.doi10.1080/13102818.2019.1696702
dc.identifier.endpage1740en_US
dc.identifier.issn1310-2818
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85076151952
dc.identifier.scopusqualityQ3
dc.identifier.startpage1733en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/13102818.2019.1696702
dc.identifier.urihttps://hdl.handle.net/11468/7811
dc.identifier.volume33en_US
dc.identifier.wosWOS:000500317300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkdağ, Memet Zülküf
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBiotechnology and Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCellular phoneen_US
dc.subjectDNA damageen_US
dc.subjectOxidative stressen_US
dc.subjectRadiofrequency radiationen_US
dc.subjectTestesen_US
dc.titleSingle-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phonesen_US
dc.titleSingle-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones
dc.typeArticleen_US

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