Normal thyroid-stimulating hormone levels, autoimmune activation, and coronary heart disease risk

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dc.contributor.authorOnat, Altan
dc.contributor.authorAydin, Mesut
dc.contributor.authorCan, Gunay
dc.contributor.authorCelik, Etem
dc.contributor.authorAltay, Servet
dc.contributor.authorKaragoz, Ahmet
dc.contributor.authorAdemoglu, Evin
dc.date.accessioned2024-04-24T16:02:39Z
dc.date.available2024-04-24T16:02:39Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractWhether euthyroid status affects cardiovascular disease risk is unclear. We aimed to investigate whether serum thyroid-stimulating hormone (TSH) levels within the normal range are related to the risk of coronary heart disease (CHD). In participants of the Turkish Adult Risk Factor Study (mean age 52.7 +/- A 11.5), in whom TSH was measured in the 2004/05 survey, cross-sectional and longitudinal analyses were performed. Subjects with TSH concentrations < 0.3 and > 4.2 mIU/L were excluded to ensure euthyroid status leaving 956 individuals as the study sample. Mean follow-up was 4.81 +/- A 1.3 years. Men had 18 % lower (p < 0.001) geometric mean TSH levels (1.10 mIU/L) than women (1.35 mIU/L). Correlations of TSH with risk variables were notably virtually absent except weakly positive ones in men with age and systolic blood pressure (SBP). The age-adjusted TSH mid-tertile in men was associated with lowest lipoprotein [Lp](a), apoB, and total cholesterol values. Incident CHD was predicted in Cox regression analyses in men [HR of 2.45 (95 %CI 1.05; 5.74] and in combined sexes by the lowest compared with the highest TSH tertile, after adjustment for age, smoking status, SBP, and LDL-cholesterol. Analysis for combined prevalent and incident CHD stratified by metabolic syndrome (MetS) confirmed the independent association with the lowest TSH tertile in men, specifically in men without MetS. TSH levels within normal range, low due to partial assay failure, may manifest as independent predictors of incident CHD, particularly in middle-aged men. Autoimmune responses involving serum Lp(a) under oxidative stress might be implicated mechanistically.en_US
dc.description.sponsorshipTurkish Society of Cardiologyen_US
dc.description.sponsorshipWe thank the Turkish Society of Cardiology and the various pharmaceutical companies (Istanbul) for financial support of the Turkish Adult Risk Factor study over the years.en_US
dc.identifier.doi10.1007/s12020-014-0269-z
dc.identifier.endpage226en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue1en_US
dc.identifier.pmid24794068
dc.identifier.scopus2-s2.0-84938602682
dc.identifier.scopusqualityQ2
dc.identifier.startpage218en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-014-0269-z
dc.identifier.urihttps://hdl.handle.net/11468/14867
dc.identifier.volume48en_US
dc.identifier.wosWOS:000349334800031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmunityen_US
dc.subjectCoronary Heart Disease Risken_US
dc.subjectLipoprotein(A)en_US
dc.subjectSerum Tshen_US
dc.subjectThyroid Statusen_US
dc.titleNormal thyroid-stimulating hormone levels, autoimmune activation, and coronary heart disease risken_US
dc.titleNormal thyroid-stimulating hormone levels, autoimmune activation, and coronary heart disease risk
dc.typeArticleen_US

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