Serum Vitamin B12, Folic Acid and Ferritin Levels in Patients with Migraine

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dc.contributor.authorAcar, Abdullah
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorYucel, Yavuz
dc.contributor.authorCevik, Mehmet Ugur
dc.contributor.authorGuzel, Isil
dc.contributor.authorColpan, Leyla
dc.date.accessioned2024-04-24T17:38:04Z
dc.date.available2024-04-24T17:38:04Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: It has been reported that disability due to migraine may be reduced with homocysteine-lowering treatment including folic acid and vitamin B12. In addition, periaqueductal gray matter iron deposits have been found recently to be increased in migraine patients. There are few studies regarding vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine. The aim of this study was to measure vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine and to compare them with the control group. Patients and Methods: Fifty-one consecutive newly diagnosed migraine patients who did not receive any vitamin supplement medication were enrolled. The study group consisted of 51 patients suffering from migraine with aura (n= 23) and migraine without aura (n= 28). The control group consisted of 28 healthy participants without history of headache, anemia or vitamin supplement. Serum vitamin B12, folic acid, ferritin, and transferrin levels were measured using a chemiluminescence method. Results: Migraine patients had significantly lower concentrations of vitamin B12 and folic acid compared with the healthy controls (for vitamin B12: 215.6 +/- 133.7 pg/mL vs. 289.9 +/- 12 pg/mL, respectively, p= 0.005; for folic acid: 6.74 (+/-) 4.31 pg/mL vs. 8.47 +/- 1.85 pg/mL, respectively, p= 0.048). The vitamin B12 levels were found to be significantly lower during attacks in migraine patients than in interictal periods (177.3 +/- 139.2 pg/mL vs. 252.5 +/- 119.5 pg/mL, p= 0.043). There were no differences in folic acid, and transferrin levels during attacks versus in the interictal period in patients with migraine (p>0.05). The ferritin levels were found to be significantly lower during attacks in migraine patients than in interictal periods (43.4 +/- 41.1 mg/mL vs. 75.4 +/- 51.7 mg/mL, respectively, p= 0.018). Conclusion: Migraine patients had lower serum vitamin B12 and folic acid levels than healthy subjects. These findings support that vitamin B12 and folic acid may have a role in migraine pathogenesis and may be included in migraine prophylaxis. Further, this study indicated that iron homeostasis is disturbed in migraine attacks.en_US
dc.identifier.endpage95en_US
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-79959840640
dc.identifier.scopusqualityQ4
dc.identifier.startpage90en_US
dc.identifier.urihttps://hdl.handle.net/11468/21308
dc.identifier.volume17en_US
dc.identifier.wosWOS:000217522600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherTurkish Neurological Socen_US
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraine Disordersen_US
dc.subjectVitamin B12en_US
dc.subjectFolic Aciden_US
dc.subjectFerritinsen_US
dc.titleSerum Vitamin B12, Folic Acid and Ferritin Levels in Patients with Migraineen_US
dc.titleSerum Vitamin B12, Folic Acid and Ferritin Levels in Patients with Migraine
dc.typeArticleen_US

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