Serum Vitamin B12, Folic Acid and Ferritin Levels in Patients with Migraine
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Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurological Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: It has been reported that disability due to migraine may be reduced with homocysteine-lowering treatment including folic acid and vitamin B12. In addition, periaqueductal gray matter iron deposits have been found recently to be increased in migraine patients. There are few studies regarding vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine. The aim of this study was to measure vitamin B12, folic acid, ferritin, and transferrin levels in patients with migraine and to compare them with the control group. Patients and Methods: Fifty-one consecutive newly diagnosed migraine patients who did not receive any vitamin supplement medication were enrolled. The study group consisted of 51 patients suffering from migraine with aura (n= 23) and migraine without aura (n= 28). The control group consisted of 28 healthy participants without history of headache, anemia or vitamin supplement. Serum vitamin B12, folic acid, ferritin, and transferrin levels were measured using a chemiluminescence method. Results: Migraine patients had significantly lower concentrations of vitamin B12 and folic acid compared with the healthy controls (for vitamin B12: 215.6 +/- 133.7 pg/mL vs. 289.9 +/- 12 pg/mL, respectively, p= 0.005; for folic acid: 6.74 (+/-) 4.31 pg/mL vs. 8.47 +/- 1.85 pg/mL, respectively, p= 0.048). The vitamin B12 levels were found to be significantly lower during attacks in migraine patients than in interictal periods (177.3 +/- 139.2 pg/mL vs. 252.5 +/- 119.5 pg/mL, p= 0.043). There were no differences in folic acid, and transferrin levels during attacks versus in the interictal period in patients with migraine (p>0.05). The ferritin levels were found to be significantly lower during attacks in migraine patients than in interictal periods (43.4 +/- 41.1 mg/mL vs. 75.4 +/- 51.7 mg/mL, respectively, p= 0.018). Conclusion: Migraine patients had lower serum vitamin B12 and folic acid levels than healthy subjects. These findings support that vitamin B12 and folic acid may have a role in migraine pathogenesis and may be included in migraine prophylaxis. Further, this study indicated that iron homeostasis is disturbed in migraine attacks.
Açıklama
Anahtar Kelimeler
Migraine Disorders, Vitamin B12, Folic Acid, Ferritins
Kaynak
Turkish Journal of Neurology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
17
Sayı
2
