New hormones to predict the severity of gallstone-induced acute pancreatitis

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dc.contributor.authorUlger, Burak Veli
dc.contributor.authorGul, Mesut
dc.contributor.authorUslukaya, Omer
dc.contributor.authorOguz, Abdullah
dc.contributor.authorBozdag, Zubeyir
dc.contributor.authorYuksel, Hatice
dc.contributor.authorBoyuk, Abdullah
dc.date.accessioned2024-04-24T17:27:30Z
dc.date.available2024-04-24T17:27:30Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description48th Congress of the European-Society-for-Surgical-Research -- MAY 29-JUN 01, 2013 -- Istanbul, TURKEYen_US
dc.description.abstractBackground/Aims: Levels of the hormones ghrelin and leptin in rat models of acute pancreatitis (AP) have been investigated in several experimental studies. However, there are very few clinical studies addressing the connection between hormone levels and AP. A few recent studies investigating the changes in ghrelin and leptin levels in patients with AP have been reported; however, our study is the first clinical study to investigate the change of nesfatin-1 levels in patients with gallstone-induced AP. Materials and Methods: Forty patients were enrolled in this study, eight of which presented with severe AP. Two blood samples were obtained from each study patient. The first blood samples were obtained at patient admission to the hospital and the second was obtained at patient discharge. All samples were collected after at least 6 h of fasting. Plasma nesfatin-1, leptin, and ghrelin levels were measured. Results: In all 40 patients, nesfatin-1 and leptin levels were higher at admission and had decreased at discharge. In contrast, the ghrelin levels at discharge were significantly higher than those at admission. Only the changes in these hormones in the mild AP group were significant. Conclusion: Levels of these hormones were altered during the course of gallstone-induced AP. These changes might be associated with the clinical outcomes of the disease. To clarify whether the magnitude of the change in hormone levels at AP onset can be used as a biomarkers to predict the severity of the disease requires further investigation.en_US
dc.description.sponsorshipEuropean Soc Surg Resen_US
dc.identifier.doi10.5152/tjg.2014.6201
dc.identifier.endpage717en_US
dc.identifier.issn2148-5607
dc.identifier.issue6en_US
dc.identifier.pmid25599787en_US
dc.identifier.startpage714en_US
dc.identifier.trdizinid235422en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2014.6201
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/235422
dc.identifier.urihttps://hdl.handle.net/11468/20007
dc.identifier.volume25en_US
dc.identifier.wosWOS:000349080900021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGallstone-Induced Acute Pancreatitisen_US
dc.subjectNesfatin-1en_US
dc.subjectGhrelinen_US
dc.subjectLeptinen_US
dc.titleNew hormones to predict the severity of gallstone-induced acute pancreatitisen_US
dc.typeConference Objecten_US

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