Vitamin D deficiency in patients with chronic hepatitis D viral infection

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dc.authorid0000-0002-2677-3971en_US
dc.authorid0000-0002-2648-2824en_US
dc.authorid0000-0002-0547-4139en_US
dc.contributor.authorUçmak, Feyzullah
dc.contributor.authorYılmaz, Ahmet
dc.contributor.authorEkin, Nazım
dc.contributor.authorEkinci, Aysun
dc.contributor.authorSolmaz, İhsan
dc.contributor.authorŞenateş, Ebubekir
dc.date.accessioned2022-12-05T12:25:46Z
dc.date.available2022-12-05T12:25:46Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractAim of the study: Vitamin D deficiency is known to be associated with disease severity, unresponsiveness to treatment, and morbidity among patients with chronic viral hepatitis B and C, autoimmune hepatitis, and alcoholic hepatitis. This study aims to research vitamin D levels in patients suffering from cirrhotic and non-cirrhotic phases of hepatitis D. Material and methods: 170 individuals in total were included in the study in the form of two groups: the first group of 100 patients with chronic hepatitis D (CHD), 30 of whom had cirrhosis, and the second control group of 70 individuals with similar characteristics to those of the first group in terms of age, type, and seasonal sampling. Levels of 25-hydroxy vitamin D [25(OH)D] were measured in the serum collected from patients and the control group. Results: The lowest 25(OH)D levels were identified in patients with cirrhotic CHD. When these levels were compared with those of the control group, they were found to be significant (15.30 +/- 6.92 and 18.90 +/- 8.30 ng/ml, respectively, p = 0.04). 25(OH)D deficiency (< 10 ng/ml) was detected at significantly higher rates in patients with both cirrhotic and non-cirrhotic CHD compared to the healthy controls (30%, 25%, and 8.5%, respectively, p = 0.01). A significant correlation was established between 25(OH)D levels and bilirubin in patients with CHD (r = 0.252, p = 0.012). Multivariate analysis showed that chronic hepatitis D (odds ratio [OR] = 3.608, 95% confidence interval [CI]: 1.31-9.89, p = 0.013) and age (OR = 1.04, 95% CI: 1.00-1.08, p = 0.033) were associated with vitamin D deficiency. Conclusions: Frequency of 25(OH)D vitamin deficiency is higher in patients with CHD. The identification of vitamin D levels and the replacement of any deficiency may create a positive effect on disease progression, morbidity, and mortality levels.en_US
dc.identifier.citationUçmak, F., Yılmaz, A., Ekin, N., Ekinci, A., Solmaz, I. ve Şenateş, E. (2021). Vitamin D deficiency in patients with chronic hepatitis D viral infection. Clinical and Experimental Hepatology, 7(2), 141-148.en_US
dc.identifier.doi10.5114/ceh.2021.106505
dc.identifier.endpage148en_US
dc.identifier.issn2392-1099
dc.identifier.issn2449-8238
dc.identifier.issue2en_US
dc.identifier.pmid34295980
dc.identifier.scopus2-s2.0-85113774045
dc.identifier.scopusqualityQ3
dc.identifier.startpage141en_US
dc.identifier.urihttps://www.termedia.pl/Vitamin-D-deficiency-in-patients-with-chronic-r-nhepatitis-D-viral-infection,80,44204,1,1.html
dc.identifier.urihttps://hdl.handle.net/11468/10943
dc.identifier.volume7en_US
dc.identifier.wosWOS:000672794700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Feyzullah
dc.institutionauthorYılmaz, Ahmet
dc.institutionauthorEkinci, Aysun
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofClinical and Experimental Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis delta virusen_US
dc.subjectLiver cirrhosisen_US
dc.subject25-hydroxyvitamin D-2en_US
dc.titleVitamin D deficiency in patients with chronic hepatitis D viral infectionen_US
dc.titleVitamin D deficiency in patients with chronic hepatitis D viral infection
dc.typeArticleen_US

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