Association of apolipoprotein E genotypes with prognosis in multiple sclerosis

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dc.contributor.authorTamam, Y.
dc.contributor.authorTasdemir, N.
dc.contributor.authorYalman, M.
dc.contributor.authorTamam, B.
dc.date.accessioned2024-04-24T17:33:16Z
dc.date.available2024-04-24T17:33:16Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Although the association between apolipoprotein E (APOE) genetic polymorphisms and multiple sclerosis (MS), has been debated, the presence of the epsilon 4 allele has been associated with an aggressive disease progression. Objectives: Present study aimed to investigate whether or not the APOE allele has an impact on disease progression in patients with MS. The study investigated the presence and clinical correlations of certain APOE genotypes in patients with MS. Materials and Methods: Fifty patients were enrolled in the study. APOE genotype was determined by polymerase chain reaction (PCR), the total apoE level was established using the nephelometric method. Expanded Disability Status Scale (EDSS) scores were also established. The progression index (PI) was calculated as the EDSS score/disease duration. Results: The most common APOE genotype in MS patients was epsilon 3/epsilon 3 (82.0%). Male patients with MS were significantly more likely to have epsilon 4, and at baseline, the disease duration was shorter, the EDSS scores were higher, the serum total ApoE levels were lower, and the PI was significantly higher. The MS onset age, clinical types, EDSS scores, and PI were not significantly correlated with epsilon 4 allele-positive. Visual onset and sensory onset are good prognostic factors. There were no patients with visual onset and few patients with sensory onset in the epsilon 4-positive group. Conclusions: The present study established male patients with MS had a higher APOE epsilon 4 frequency and disease severity, but were likely to have lower serum ApoE levels. An additional study is needed with a larger sample to include all genotypes.en_US
dc.identifier.endpage1130en_US
dc.identifier.issn1128-3602
dc.identifier.issue10en_US
dc.identifier.pmid22165672
dc.identifier.scopus2-s2.0-82455206148
dc.identifier.scopusqualityQ2
dc.identifier.startpage1122en_US
dc.identifier.urihttps://hdl.handle.net/11468/20577
dc.identifier.volume15en_US
dc.identifier.wosWOS:000296917400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectApoeen_US
dc.subjectGenotypeen_US
dc.subjectPrognosisen_US
dc.subjectEdssen_US
dc.titleAssociation of apolipoprotein E genotypes with prognosis in multiple sclerosisen_US
dc.titleAssociation of apolipoprotein E genotypes with prognosis in multiple sclerosis
dc.typeArticleen_US

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