The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ10) in children with pandemic influenza (H1N1) and seasonal flu

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dc.contributor.authorKelekci, S.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorSen, V.
dc.contributor.authorYolbas, I.
dc.contributor.authorUluca, U.
dc.contributor.authorTan, I.
dc.contributor.authorGurkan, M. F.
dc.date.accessioned2024-04-24T17:39:57Z
dc.date.available2024-04-24T17:39:57Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND AND AIM, This study was planned to evaluate the relationships between the levels of total antioxidant capacity (TAC) and Coenzyme 0 (Coal 0) and clinical outcome in hospitalized children with pandemic influenza (H1N1). Serum copper (Cu) and zinc (Zn) levels were also determined to evaluate the changings of oxidative stress's enzyme activities depending on their cofactor concentrations. PATIENTS AND METHODS, Children with suspected H1N1 virus infection were hospitalized and nasal swabs were sent to laboratory for confirmation of H1N1 by rRT-PCR assay. Age and sex matched 31 healthy children were included as Control Group. Total antioxidant capacity and CoQ10 were determined by spectrophotometry and HPLC, respectively, and Cu and Zn were determined using atomic absorption spectrometer. RESULTS, Totally 28 children had H1N1 and 37 children had seasonal influenza (SI). TAC, CoQ10 and Zn levels were found to be significantly decreased in H1N1 patients (1.01 +/- 0.19, 752.2 +/- 163, 69 +/- 27, respectively) compared to Control Group (1.64 +/- 0.36, 934 +/- 21, 92 +/- 4, respectively). Seasonal Influenza group had significantly decreased TAC and Zn levels (1.31 +/- 0.27, 78 +/- 34 respectively) compared with control group (1.64 +/- 0.36, 92 +/- 41, respectively). CoQ10 levels were also found as decreased in H1N1 compared to seasonal influenza (752.2 +/- 163 vs 1022 +/- 199, p = 0.003). There was a significant correlation between CoQ10 levels of sera and chest radiographic findings of patients with H1N1 pneumonia. No significant differences were found in serum Cu levels between patients with H1N1 and SI or control group (150 +/- 45 vs 127 +/- 37, p = 0.215). CONCLUSIONS, Pandemic influenza infection had increased oxidative stress compared to the seasonal influenza.en_US
dc.identifier.endpage1038en_US
dc.identifier.issn1128-3602
dc.identifier.issue8en_US
dc.identifier.pmid22913153
dc.identifier.scopus2-s2.0-84865812036
dc.identifier.scopusqualityQ2
dc.identifier.startpage1033en_US
dc.identifier.urihttps://hdl.handle.net/11468/21471
dc.identifier.volume16en_US
dc.identifier.wosWOS:000307486400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectCoenzyme Qen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.titleThe relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ10) in children with pandemic influenza (H1N1) and seasonal fluen_US
dc.titleThe relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ10) in children with pandemic influenza (H1N1) and seasonal flu
dc.typeArticleen_US

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