Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps

Basit Öğe Kaydı
dc.contributor.authorAydogan, Hakan
dc.contributor.authorGurlek, Ali
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAskar, Ibrahim
dc.contributor.authorBay-Karabulut, Aysun
dc.contributor.authorAydogan, Nilay
dc.contributor.authorFariz, Alpay
dc.date.accessioned2024-04-24T16:10:56Z
dc.date.available2024-04-24T16:10:56Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Reperfusion injury is a phenomenon that occurs when tissues are subjected to ischaemia for a variable period of time, after which they are reperfused. Many factors have been implicated in the cause of reperfusion injury including free radicals and neutrophils. Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is an active component of propolis from honeybee; it has anti-inflammatory and immunomodulatory properties, and protective effects against ischaemia-reperfusion (I/R) injury. We investigated the effects of CAPE on the survival of skin flaps in the rat. Materials and methods: Eighteen Wistar rats were used, and randomly divided into three groups (n = 6 rats each group): the control group (Group 1), ethanot group (Group 2), and CAPE group (Group 3). A caudally based rectangular flap, 3 x 10 cm in size, was elevated on the back of the rat, according to the method described by Khouri and colleagues. The flap was sutured back into its original place. In the control group, saline 0.2 ml/day was given intraperitoneally (i.p.). Five percent ethanol 0.2 ml/day was administered i.p. in the ethanol group, and CAPE 50 mu mol/kg/day i.p. in the CAPE group. To observe the effects of CAPE, levels of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were measured from extracted skin tissue. Flap viability was evaluated seven days after the initial operation, measuring necrotic areas of flaps and total flap areas. Results: MDA and NO levels were significantly decreased in CAPE group; and however, GSH, GSH-Px, and SOD enzyme activities were significantly increased in CAPE group. We believed that the CAPE had beneficial effects to improve the survival of skin flaps since it has antioxidative and anti-inflammatory properties, and protective effects against I/II injury. (C) 2006 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bjps.2006.01.030
dc.identifier.endpage568en_US
dc.identifier.issn1748-6815
dc.identifier.issue5en_US
dc.identifier.pmid17399667
dc.identifier.scopus2-s2.0-33947589696
dc.identifier.scopusqualityQ2
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjps.2006.01.030
dc.identifier.urihttps://hdl.handle.net/11468/15193
dc.identifier.volume60en_US
dc.identifier.wosWOS:000246733600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Plastic Reconstructive and Aesthetic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester (Cape)en_US
dc.subjectIschaemia-Reperfusion Injuryen_US
dc.subjectRandom Pattern Skin Flapen_US
dc.titleBeneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flapsen_US
dc.titleBeneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu